5-氟吲哚
5-氟吲哚结构式
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常用名 | 5-氟吲哚 | 英文名 | 5-Fluoroindole |
|---|---|---|---|---|
| CAS号 | 399-52-0 | 分子量 | 135.14 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 258.0±13.0 °C at 760 mmHg | |
| 分子式 | C8H6FN | 熔点 | 45-48 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 109.9±19.8 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Ionization potentials of fluoroindoles and the origin of nonexponential tryptophan fluorescence decay in proteins.
J. Am. Chem. Soc. 127(11) , 4104-13, (2005) This work reports an explanation for the unusual monoexponential fluorescence decay of 5-fluorotryptophan (5FTrp) in single-Trp mutant proteins [Broos, J.; Maddalena, F.; Hesp, B. H. J. Am. Chem. Soc. 2004, 126, 22-23] and substantially clarifies the origin o... |
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Regulation of tryptophan synthase gene expression in Chlamydia trachomatis.
Mol. Microbiol. 49(5) , 1347-59, (2003) We previously reported that Chlamydia trachomatis expresses the genes encoding tryptophan synthase (trpA and trpB). The results presented here indicate that C. trachomatis also expresses the tryptophan repressor gene (trpR). The complement of genes regulated ... |
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Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
J. Med. Chem. 52 , 4694-715, (2009) We describe a novel fragment library termed fragments of life (FOL) for structure-based drug discovery. The FOL library includes natural small molecules of life, derivatives thereof, and biaryl protein architecture mimetics. The choice of fragments facilitate... |
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Pictet-Spengler based synthesis of a bisarylmaleimide glycogen synthase kinase-3 inhibitor.
Org. Lett. 12 , 3700-3703, (2010) A practical synthesis of the glycogen synthase kinase-3 (GSK3) inhibitor bisarylmaleimide 1 has been accomplished employing Pictet-Spengler methodology to access the indole 7-position in preparing the benzodiazepine tricyclic fragment. A seven-step linear seq... |
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A1H/19F minicoil NMR probe for solid-state NMR: Application to 5-fluoroindoles
J. Magn. Reson. 178(1) , 65-71, (2006) We show that it is feasible to use a minicoil for solid-state 19F 1H NMR experiments that has short pulse widths, good RF homogeneity, and excellent signal-to-noise for small samples while using low power amplifiers typical to liquid-state NMR. The closely sp... |
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Identification of the gene encoding the tryptophan synthase beta-subunit from Chlamydomonas reinhardtii.
Plant Physiol. 117(2) , 455-64, (1998) We report the isolation of a Chlamydomonas reinhardtii cDNA that encodes the beta-subunit of tryptophan synthase (TSB). This cDNA was cloned by functional complementation of a trp-operon-deleted strain of Escherichia coli. Hybridization analysis indicated tha... |
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5-Fluoroindole resistance identifies tryptophan synthase beta subunit mutants in Arabidopsis thaliana.
Genetics 140(1) , 303-13, (1995) A study of the biochemical genetics of the Arabidopsis thaliana tryptophan synthase beta subunit was initiated by characterization of mutants resistant to the inhibitor 5-fluoroindole. Thirteen recessive mutations were recovered that are allelic to trp2-1, a ... |
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Simple and inexpensive incorporation of 19F-tryptophan for protein NMR spectroscopy.
Chem. Commun. (Camb.) 48(86) , 10681-3, (2012) Fluorine-containing amino acids are valuable probes for the biophysical characterization of proteins. Current methods for (19)F-labeled protein production involve time-consuming genetic manipulation, compromised expression systems and expensive reagents. We s... |