SRPKINHIBITOR
SRPKINHIBITOR结构式
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常用名 | SRPKINHIBITOR | 英文名 | SRPIN340 |
|---|---|---|---|---|
| CAS号 | 218156-96-8 | 分子量 | 349.350 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 395.9±42.0 °C at 760 mmHg | |
| 分子式 | C18H18F3N3O | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 193.3±27.9 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma.
Br. J. Cancer 111(3) , 477-85, (2014) Current therapies for metastatic melanoma are targeted either at cancer mutations driving growth (e.g., vemurafenib) or immune-based therapies (e.g., ipilimumab). Tumour progression also requires angiogenesis, which is regulated by VEGF-A, itself alternativel... |
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Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization.
Mol. Vis. 19 , 536-43, (2013) To investigate the applicability of serine/arginine-rich protein kinase (SRPK)-specific inhibitor, SRPIN340, for attenuation of choroidal neovascularization (CNV) formation using a mouse model.Laser photocoagulation was performed to induce CNV in C57BL/6J mic... |
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Dysregulation of splicing proteins in head and neck squamous cell carcinoma.
Cancer Biol. Ther. 17 , 219-29, (2016) Signaling plays an important role in regulating all cellular pathways. Altered signaling is one of the hallmarks of cancers. Phosphoproteomics enables interrogation of kinase mediated signaling pathways in biological systems. In cancers, this approach can be ... |