TAPROSTENE SODIUM
TAPROSTENE SODIUM结构式
|
常用名 | TAPROSTENE SODIUM | 英文名 | TAPROSTENE SODIUM |
|---|---|---|---|---|
| CAS号 | 87440-45-7 | 分子量 | 420.47400 | |
| 密度 | N/A | 沸点 | 609.4ºC at 760 mmHg | |
| 分子式 | C24H29NaO5 | 熔点 | 173-182.5ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 209.2ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
|
In vitro analysis of synergistic effects of fibrinolytic agents and prostacyclin analogues.
Haemostasis 27(4) , 184-92, (1997) We investigated the in vitro thrombolytic effects of streptokinase, urokinase, alteplase and saruplase, alone or in combination, with the prostacyclin analogues, iloprost and taprostene. Human platelet-rich plasma was stimulated with collagen (1 microgram/ml)... |
|
|
[Effect of the prostacyclin analog taprostene on ischemic ST-segment depression in the stress ECG of coronary patients].
Z. Kardiol. 83(4) , 258-63, (1994) Prostaglandins and prostacyclin are potent vasodilators with marked hemodynamic effects, i.e., both improve cardiac function and possibly cause myocardial ischemia. In order to assess the stable prostacyclin analogon taprostene (T) we first performed an open ... |
|
|
Effects of prostacyclin on hearing recovery after repetitive noise and on histomorphology of the inner ear in the guinea pig.
ORL J. Otorhinolaryngol. Relat. Spec. 56(6) , 305-9, (1994) A probable relation between prostaglandin formation and the pathophysiology of hearing loss led to the application of the potent vasodilator prostacyclin in the treatment of inner ear disorders. Two drugs may be administered to humans: (1) unstable natural pr... |
|
|
Partial agonism of taprostene at prostanoid IP receptors in vascular preparations from guinea-pig, rat, and mouse.
J. Cardiovasc. Pharmacol. 43(6) , 795-807, (2004) This study investigates whether incomplete relaxation of vascular smooth muscle preparations induced by the prostacyclin analogue taprostene is due to partial agonism at prostanoid IP receptors. In the presence of the prostanoid EP4 receptor antagonist AH 238... |
|
|
Agonists can discriminate between cloned human and mouse prostacyclin receptors.
Prostaglandins Leukot. Essent. Fatty Acids 70(5) , 423-9, (2004) The ability of prostacyclin analogues to stimulate adenylyl cyclase (AC) and phospholipase C (PLC) in Chinese hamster ovary (CHO) cells expressing cloned human (hIP) or cloned mouse (mIP) prostacyclin receptors has been compared. For hIP, the order of potency... |
|
|
Investigation of the agonist activity of prostacyclin analogues on prostanoid EP4 receptors using GW 627368 and taprostene: evidence for species differences.
Prostaglandins Leukot. Essent. Fatty Acids 72(4) , 289-99, (2005) The possibility that the prostacyclin analogues AFP-07 and cicaprost relax saphenous vein preparations of pig, guinea-pig and rabbit by simultaneously activating prostanoid EP4 and IP (prostacyclin) receptors was investigated using the high-affinity EP4 antag... |
|
|
The beagle dog as a predictor of gastrointestinal findings in humans caused by the prostacyclin analogue taprostene.
Exp. Toxicol. Pathol. 46(1) , 71-3, (1994) Beagle dogs were exposed orally to the prostacyclin analogue taprostene for four weeks. Dose levels of 200-3000 micrograms/kg body weight/day were used. Specific activity of taprostene on the digestive system compared to other species is reported. It is chara... |
|
|
Critical limb ischaemia: a case against Consensus II.
Int. Angiol. 14(4) , 353-6, (1995) Critical limb ischaemia (CLI) is a serious clinical condition that often immediately precedes limb loss. The Consensus Documents of 1989 and 1991 attempted to define CLI and give direction to its investigation and management. Whilst the need for such a consen... |
|
|
Neutrophil count and amputation in critical limb ischaemia.
Int. Angiol. 18(2) , 140-4, (1999) The white blood cell count (WCC) is known to be predictive of cardiac and cerebral vascular events. No one has yet investigated this in critical limb ischaemia (CLI).Baseline WCC was examined in relation to lower limb amputation 6 months after a 4 week treatm... |
|
|
Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cells.
J. Immunol. 183(10) , 6788-99, (2009) Prostacyclin receptor (IP-receptor) agonists display anti-inflammatory and antiviral activity in cell-based assays and in preclinical models of asthma and chronic obstructive pulmonary disease. In this study, we have extended these observations by demonstrati... |