酒石酸艾芬地尔
酒石酸艾芬地尔结构式
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常用名 | 酒石酸艾芬地尔 | 英文名 | ifenprodil tartrate |
|---|---|---|---|---|
| CAS号 | 23210-58-4 | 分子量 | 400.49 | |
| 密度 | N/A | 沸点 | 493.5ºC at 760mmHg | |
| 分子式 | C21H27NO2.1/2C4H6O6 | 熔点 | 178-180ºC | |
| MSDS | 中文版 美版 | 闪点 | 248.7ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.
J. Neurosci. 33(38) , 15259-71, (2013) Panic attacks are a hallmark in panic disorder (PAND). During the panic attack, a strong association with the surrounding context is established suggesting that the hippocampus may be critically involved in the pathophysiology of PAND, given its role in conte... |
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Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory.
J. Neurosci. 33(3) , 1109-15, (2013) Signaling at NMDA receptors (NMDARs) is known to be important for memory reconsolidation, but while most studies show that NMDAR antagonists prevent memory restabilization and produce amnesia, others have shown that GluN2B-selective NMDAR antagonists prevent ... |
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Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models.
Pain 153 , 1022-1029, (2012) N-Methyl-d-aspartate (NMDA) receptors are thought to play an important role in the processes of central sensitization and pathogenesis of neuropathic pain, particularly after spinal cord injury (SCI). NMDA antagonists effectively reduce neuropathic pain, but ... |
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Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors.
PLoS ONE 7(5) , e37989, (2012) In addition to both the α1 adrenergic receptor and N-methyl-D-aspartate (NMDA) receptor antagonists, ifenprodil binds to the sigma receptor subtypes 1 and 2. In this study, we examined the effects of ifenprodil on nerve growth factor (NGF)-induced neurite out... |
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Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.
Br. J. Pharmacol. 166(3) , 1002-17, (2012) Neurocognitive disorders afflict approximately 20% of HIV-infected patients. HIV-1-infected cells in the brain shed viral proteins such as transactivator of transcription (Tat). Tat elicits cell death and synapse loss via processes initiated by NMDA receptor ... |
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Effect of ifenprodil on GluN1/GluN2B N-methyl-D-aspartate receptor gating.
Mol. Pharmacol. 83(1) , 9-21, (2013) Ifenprodil is an allosteric inhibitor of GluN1/GluN2B N-methyl-D-aspartate receptors. Despite its widespread use as a prototype for drug development and a subtype-selective tool for physiologic experiments, its precise effect on GluN1/GluN2B gating is yet to ... |
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Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.
Neuropharmacology 63(6) , 974-82, (2012) Glutamate-induced delayed calcium dysregulation (DCD) is causally linked to excitotoxic neuronal death. The mechanisms of DCD are not completely understood, but it has been proposed that the excessive influx of external Ca(2+) is essential for DCD. The NMDA-s... |
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Ifenprodil effects on GluN2B-containing glutamate receptors.
Mol. Pharmacol. 82(6) , 1074-81, (2012) N-Methyl-d-aspartate (NMDA) receptors are glutamate- and glycine-gated channels that mediate fast excitatory transmission in the central nervous system and are critical to synaptic development, plasticity, and integration. They have a rich complement of modul... |
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Amino-terminal ligands prolong NMDA Receptor-mediated EPSCs.
J. Neurosci. 32(23) , 8065-73, (2012) The amino-terminal domains of NMDA receptor subunits are important for receptor assembly and desensitization, and incorporate the high-affinity binding sites for zinc and ifenprodil. These amino-terminal ligands are thought of as subunit-specific receptor inh... |
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Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors.
Neuroscience 165 , 525-34, (2009) Excess glutamate release and stimulation of post-synaptic glutamatergic receptors have been implicated in the pathophysiology of many neurological diseases. The hippocampus, and the pyramidal cell layer of the cornu ammonus 1 (CA1) region in particular, has b... |