L-精氨酰胺二盐酸盐
L-精氨酰胺二盐酸盐结构式
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常用名 | L-精氨酰胺二盐酸盐 | 英文名 | H-Arg-NH2.2HCl |
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| CAS号 | 14975-30-5 | 分子量 | 246.138 | |
| 密度 | 1.46g/cm3 | 沸点 | 446.4ºC at 760 mmHg | |
| 分子式 | C6H17Cl2N5O | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 223.8ºC | |
| 符号 |
GHS07, GHS08 |
信号词 | Danger |
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Immobilization of trypsin in organic and aqueous media for enzymatic peptide synthesis and hydrolysis reactions.
BMC Biotechnol. 15 , 77, (2015) Immobilization of enzymes onto different carriers increases enzyme's stability and reusability within biotechnological and pharmaceutical applications. However, some immobilization techniques are associated with loss of enzymatic specificity and/or activity. ... |
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Energetic basis of molecular recognition in a DNA aptamer.
Biophys. Chem. 126(1-3) , 165-75, (2007) The thermal stability and ligand binding properties of the L-argininamide-binding DNA aptamer (5'-GATCGAAACGTAGCGCCTTCGATC-3') were studied by spectroscopic and calorimetric methods. Differential calorimetric studies showed that the uncomplexed aptamer melted... |
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N(G)-Acyl-argininamides as NPY Y(1) receptor antagonists: Influence of structurally diverse acyl substituents on stability and affinity.
Bioorg. Med. Chem. 18(17) , 6292-304, (2010) N(G)-Acylated argininamides, covering a broad range of lipophilicity (calculated logD values: -1.8-12.5), were synthesized and investigated for NPY Y(1) receptor (Y(1)R) antagonism, Y(1)R affinity and stability in buffer (N(G)-deacylation, yielding BIBP 3226)... |
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Structural features of the L-argininamide-binding DNA aptamer studied with ESI-FTMS.
Anal. Chem. 78(20) , 7259-66, (2006) The 24-mer DNA aptamer of Harada and Frankel (Harada, K.; Frankel, A. D. EMBO J. 1995, 14, 5798-5811) that binds L-argininamide (L-Arm) was studied by electrospray ionization Fourier transform mass spectrometry (ESI-FTMS). This DNA folds into a stem and loop ... |
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Red-fluorescent argininamide-type NPY Y1 receptor antagonists as pharmacological tools.
Bioorg. Med. Chem. 19(9) , 2859-78, (2011) Fluorescently labelled NPY Y(1) receptor (Y(1)R) ligands were synthesized by connecting pyrylium and cyanine dyes with the argininamide-type Y(1)R antagonist core structure by linkers, covering a wide variety in length and chemical nature, attached to the gua... |
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Biomolecular sensor based on fluorescence-labeled aptamer.
Bioorg. Med. Chem. Lett. 16(16) , 4381-4, (2006) Fluorescent DNA probes for L-argininamide were developed by a combination of DNA aptamers and fluorophore-quencher pairs. These molecules were synthesized by a combination of pre- and post-synthetic modification methods. The fluorescence-labeled aptamer could... |
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Application of the guanidine-acylguanidine bioisosteric approach to argininamide-type NPY Y₂ receptor antagonists.
ChemMedChem 6(9) , 1727-38, (2011) Strongly basic groups such as guanidine moieties are crucial structural elements, but they compromise the drug-likeness of numerous biologically active compounds, including ligands of G-protein-coupled receptors (GPCRs). As part of a project focused on the se... |
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Bivalent argininamide-type neuropeptide y y(1) antagonists do not support the hypothesis of receptor dimerisation.
ChemMedChem 4(10) , 1733-45, (2009) Bivalent ligands are potential tools to investigate the dimerisation of G-protein-coupled receptors. Based on the (R)-argininamide BIBP 3226, a potent and selective neuropeptide Y Y(1) receptor (Y(1)R) antagonist, we prepared a series of bivalent Y(1)R ligand... |
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Single-molecule study of the inhibition of HIV-1 transactivation response region DNA/DNA annealing by argininamide.
J. Am. Chem. Soc. 129(33) , 10181-8, (2007) Single-molecule spectroscopy was used to examine how a model inhibitor of HIV-1, argininamide, modulates the nucleic acid chaperone activity of the nucleocapsid protein (NC) in the minus-strand transfer step of HIV-1 reverse transcription, in vitro. In minus-... |
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New, extended hairpin form of the TAR-2 RNA domain points to the structural polymorphism at the 5' end of the HIV-2 leader RNA.
Nucleic Acids Res. 34(10) , 2984-97, (2006) The HIV-2 TAR RNA domain (TAR-2) plays a key role in the trans-activation of HIV-2 transcription as it is the target for the Tat-2 protein and several cell factors. Here, we show that the TAR-2 domain exists in vitro in two global, alternative forms: a new, e... |