阿尔达-1
阿尔达-1结构式
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常用名 | 阿尔达-1 | 英文名 | Alda 1 |
|---|---|---|---|---|
| CAS号 | 349438-38-6 | 分子量 | 324.15900 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C15H11Cl2NO3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS06, GHS09 |
信号词 | Danger |
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Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy.
J. Hepatol. 62(3) , 647-56, (2015) Mitochondrial aldehyde dehydrogenase (ALDH2) plays a critical role in the detoxification of the ethanol metabolite acetaldehyde. This study was designed to examine the impact of global ALDH2 overexpression on alcohol-induced hepatic steatosis.Wild type Friend... |
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Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice.
J. Hepatol. 62 , 1375-81, (2015) Effective therapies for alcoholic liver disease are currently unavailable. The present study tested the efficacy of Alda-1, a specific aldehyde dehydrogenase 2 (ALDH2) activator, in treating alcoholic liver disease.Male C57BL/6J mice were exposed to alcohol f... |
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Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice.
J. Am. Heart Assoc. 3(6) , e001329, (2014) Mitochondrial dysfunction has been shown to play an important role in the development of atherosclerosis and nonalcoholic fatty liver disease (NAFLD). Mitochondrial aldehyde dehydrogenase (ALDH2), an enzyme responsible for the detoxification of reactive aldeh... |
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ALDH2 protects against stroke by clearing 4-HNE.
Cell Res. 23 , 915-30, (2013) Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that metabolizes ethanol and toxic aldehydes such as 4-hydroxy-2-nonenal (4-HNE). Using an unbiased proteomic search, we identified ALDH2 deficiency in stroke-prone spontaneously hypertensive rats (SH... |