2,3-双(4-羟苯基)丙腈
2,3-双(4-羟苯基)丙腈结构式
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常用名 | 2,3-双(4-羟苯基)丙腈 | 英文名 | 2,3-bis(4-hydroxyphenyl)propionitrile |
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| CAS号 | 1428-67-7 | 分子量 | 239.269 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 449.4±35.0 °C at 760 mmHg | |
| 分子式 | C15H13NO2 | 熔点 | 203°C | |
| MSDS | 美版 | 闪点 | 225.6±25.9 °C | |
| 符号 |
GHS07, GHS09 |
信号词 | Warning |
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A precisely substituted benzopyran targets androgen refractory prostate cancer cells through selective modulation of estrogen receptors.
Toxicol. Appl. Pharmacol. 283(3) , 187-97, (2015) Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against ... |
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Classical and membrane-initiated estrogen signaling in an in vitro model of anterior hypothalamic kisspeptin neurons.
Endocrinology 156 , 2162-73, (2015) The neuropeptide kisspeptin is essential for sexual maturation and reproductive function. In particular, kisspeptin-expressing neurons in the anterior rostral periventricular area of the third ventricle are generally recognized as mediators of estrogen positi... |
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Methyltransferase-like 17 physically and functionally interacts with estrogen receptors.
IUBMB Life 67 , 861-8, (2016) Estrogen exerts its physiological and pathological functions through two estrogen receptors (ERs), ERα and ERβ, which act as transcription factors. Coregulators, including coactivators and corepressors, have been shown to be crucial for regulation of ER trans... |
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Regulation of the mouse medial prefrontal cortical synapses by endogenous estradiol.
Neuropsychopharmacology 39(9) , 2086-94, (2014) Recent studies suggest that low endogenous estradiol might be a susceptibility factor for anxiety and trauma-related disorders in women. Consistently, fear extinction, a form of inhibitory learning critical for the management of anxiety symptoms, is positivel... |
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Estrogen adversely affects the prognosis of patients with lung adenocarcinoma.
Cancer Sci. 106(1) , 51-9, (2015) Estrogen has been postulated to contribute to the development and progression of lung cancer. We examined the epidemiologic evidence, explored the characteristics of estrogen receptors (ER) in lung adenocarcinoma, and investigated the effect of estrogen on lu... |
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Characterisation of Signalling by the Endogenous GPER1 (GPR30) Receptor in an Embryonic Mouse Hippocampal Cell Line (mHippoE-18).
PLoS ONE 11 , e0152138, (2016) Estrogen can modulate neuronal development and signalling by both genomic and non-genomic pathways. Many of its rapid, non-genomic effects on nervous tissue have been suggested to be mediated via the activation of the estrogen sensitive G-protein coupled rece... |
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Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models.
J. Nutr. Biochem. 28 , 70-82, (2016) As a phytoestrogen, kaempferol (Kaem) is one of bioflavonoids, which are found in a variety of vegetables including broccoli, tea and tomato. In this study, the antiproliferative effects of Kaem in triclosn (TCS)-induced cell growth were examined in MCF-7 bre... |
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Cigarette Smoke and Estrogen Signaling in Human Airway Smooth Muscle.
Cell Physiol. Biochem. 36 , 1101-15, (2015) Cigarette smoke (CS) in active smokers and second-hand smoke exposure exacerbate respiratory disorders such as asthma and chronic bronchitis. While women are known to experience a more asthmatic response to CS than emphysema in men, there is limited informati... |
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In vivo oestrogenic modulation of Egr1 and Pitx1 gene expression in female rat pituitary gland.
J. Mol. Endocrinol. 53(3) , 355-66, (2014) EGR1 and PITX1 are transcription factors required for gonadotroph cell Lhb promoter activation. To determine changes in Egr1 and Pitx1 mRNA levels in central and peripheral pituitary stimulations, an in vivo model based on i.c.v. pulsatile (1 pulse/0.5 h over... |
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Dynamics of Immune Cell Types Within the Macaque Corpus Luteum During the Menstrual Cycle: Role of Progesterone.
Biol. Reprod. 93 , 112, (2015) The goal of the current study was to characterize the immune cell types within the primate corpus luteum (CL). Luteal tissue was collected from rhesus females at discrete intervals during the luteal phase of the natural menstrual cycle. Dispersed cells were i... |