酪氨酸磷酸化抑制剂A9
酪氨酸磷酸化抑制剂A9结构式
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常用名 | 酪氨酸磷酸化抑制剂A9 | 英文名 | Malonoben |
|---|---|---|---|---|
| CAS号 | 10537-47-0 | 分子量 | 282.380 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 386.8±37.0 °C at 760 mmHg | |
| 分子式 | C18H22N2O | 熔点 | 141-143℃ (ethanol ) | |
| MSDS | 中文版 美版 | 闪点 | 187.7±26.5 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation.
Mol. Brain 3 , 4, (2010) Group I metabotropic glutamate receptors (mGluRs) are coupled via Galphaq/11 to the activation of phospholipase Cbeta, which hydrolyzes membrane phospholipids to form inositol 1,4,5 trisphosphate and diacylglycerol. This results in the release of Ca2+ from in... |
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Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage.
FASEB J. 30 , 286-300, (2016) Itaconate is a nonamino organic acid exhibiting antimicrobial effects. It has been recently identified in cells of macrophage lineage as a product of an enzyme encoded by immunoresponsive gene 1 (Irg1), acting on the citric acid cycle intermediate cis-aconita... |
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Vesicular transport and apotransferrin in intestinal iron absorption, as shown in the Caco-2 cell model.
Am. J. Physiol. Gastrointest. Liver Physiol. 290 , G301-G309, (2006) The potential roles of vesicular transport and apotransferrin (entering from the blood) in intestinal Fe absorption were investigated using Caco-2 cell monolayers with tight junctions in bicameral chambers as a model. As shown previously, addition of 39 micro... |
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Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts.
J. Cell Sci. 114(Pt 1) , 149-160, (2001) The non-receptor tyrosine kinase Src was shown to be essential for osteoclast function in vivo. We have previously reported that engagement of (alpha)(v)(beta)(3) integrin in osteoclasts induces tyrosine phosphorylation and activation of the adhesion kinase P... |
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Collagen degradation and platelet-derived growth factor stimulate the migration of vascular smooth muscle cells.
J. Cell Sci. 113 ( Pt 11) , 2055-64, (2000) Cell migration is a key event in many biological processes and depends on signals from both extracellular matrix and soluble motogenic factors. During atherosclerotic plaque development, vascular smooth muscle cells migrate from the tunica media to the intima... |
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LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway.
Mol. Immunol. 46(5) , 962-8, (2009) Bacterial endotoxin (lipopolysaccharide or LPS) has potent pro-inflammatory properties and acts on many cell types including endothelial cells. Secretion of the CC chemokine, MCP-1 (CCL2) by LPS-activated endothelial cells contributes substantially to the pat... |
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Chemokine receptor 7 via proline-rich tyrosine kinase-2 upregulates the chemotaxis and migration ability of squamous cell carcinoma of the head and neck.
Oncol. Rep. 28(5) , 1659-64, (2012) Aberrant regulation in the chemotaxis and migration ability of cancer cells is closely associated with their metastatic activity. The chemokine receptor 7 (CCR7) has recently been shown to play an important role in regional lymph node metastasis of squamous c... |
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Modulation of intracellular calcium concentrations and T cell activation by prickly pear polyphenols.
Mol. Cell Biochem. 260(1-2) , 103-10, (2004) Opuntia ficus indica (prickly pear) polyphenolic compounds (OFPC) triggered an increase in [Ca2+]i in human Jurkat T-cell lines. Furthermore, OFPC-induced rise in [Ca2+]i was significantly curtailed in calcium-free buffer (0% Ca2+) as compared to that in 100%... |
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Establishment, characterization, and drug sensitivity of a new Ewing sarcoma cell line (SS-ES-1).
J. Pediatr. Hematol. Oncol. 32(8) , e331-7, (2010) Ewing sarcoma (ES) is one of the most malignant tumors in children and young adults. We present here a new ES cell line, SS-ES-1, established from the left thoracic tumor of a 16-year-old female patient. The SS-ES-1 cells retained genotype, morphology, and gr... |
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Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells.
Eur. J. Cell Biol. 76(1) , 33-42, (1998) To proliferate, vascular smooth muscle cells first convert from a contractile to a synthetic phenotype. Earlier studies indicate that this process is supported by fibronectin and accelerated by platelet-derived growth factor (PDGF). Here, the mechanisms in th... |