三唑仑
一般危化品
三唑仑结构式
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常用名 | 三唑仑 | 英文名 | Triazolam |
|---|---|---|---|---|
| CAS号 | 28911-01-5 | 分子量 | 343.21000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C17H12Cl2N4 | 熔点 | 209-212°C | |
| MSDS | 中文版 美版 | 闪点 | 11 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).
Forensic Sci. Int. 243 , 99-106, (2014) The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-residue pesticide analysis in food and agricultural products. ... |
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Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. |
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Development of Murine Cyp3a Knockout Chimeric Mice with Humanized Liver.
Drug Metab. Dispos. 43 , 1208-17, (2015) We developed murine CYP3A knockout ko chimeric mice with humanized liver expressing human P450S similar to those in humans and whose livers and small intestines do not express murine CYP3A this: approach may overcome effects of residual mouse metabolic enzyme... |
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Investigation of drug-drug interactions caused by human pregnane X receptor-mediated induction of CYP3A4 and CYP2C subfamilies in chimeric mice with a humanized liver.
Drug Metab. Dispos. 40(3) , 474-80, (2012) The induction of cytochrome P450 (P450) enzymes is one of the risk factors for drug-drug interactions (DDIs). To date, the human pregnane X receptor (PXR)-mediated CYP3A4 induction has been well studied. In addition to CYP3A4, the expression of CYP2C subfamil... |
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Solid-phase dispersive extraction method for analysis of benzodiazepine drugs in serum and urine samples.
J. Pharm. Biomed. Anal. 100 , 28-32, (2014) A simple yet highly efficient pretreatment method called solid-phase dispersive extraction (SPDE) was developed and used in combination with liquid chromatography/time-of-flight mass spectrometry (LC/TOF-MS) for the analysis of benzodiazepines (BZPs) in serum... |
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Identification and quantification of 34 drugs and toxic compounds in blood, urine, and gastric content using liquid chromatography with tandem mass spectrometry.
J. Sep. Sci. 38 , 1680-90, (2015) A liquid chromatography with tandem mass spectrometry method was developed for the simultaneous screening of 34 drugs and poisons in forensic cases. Blood (0.5 mL, diluted 1:1 with water) or 1.0 mL of urine was purified by solid-phase extraction. Gastric cont... |
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Development and validation of an LC-MS/MS method for the simultaneous analysis of 28 specific narcotic adulterants used in dietary supplements.
Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 1029-39, (2015) The purpose of this study was to develop a method to analyse the concentration of multiple illegal narcotics present in dietary supplements. To this end, we established and optimised a procedure using LC-MS/MS simultaneously to analyse 28 narcotic compounds i... |
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Is pomegranate juice a potential perpetrator of clinical drug-drug interactions? Review of the in vitro, preclinical and clinical evidence.
Eur. J. Drug Metab. Pharmacokinet. 38(4) , 223-9, (2013) The area of fruit juice-drug interaction has received wide attention with numerous scientific and clinical investigations performed and reported for scores of drugs metabolized by CYP3A4/CYP2C9. While grapefruit juice has been extensively studied with respect... |
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Sensitive UPLC-MS-MS assay for 21 benzodiazepine drugs and metabolites, zolpidem and zopiclone in serum or plasma.
J. Anal. Toxicol. 36(7) , 472-6, (2012) This paper reports an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method to quantitate 21 benzodiazepines, zolpidem and zopiclone in serum and plasma. After liquid-liquid extraction, an Acquity UPLC with a TQ Detector and BEH... |
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Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor.
J. Pharmacol. Exp. Ther. 311(2) , 537-46, (2004) Clinically used benzodiazepine and nonbenzodiazepine sedative-hypnotic agents for the treatment of insomnia produce their therapeutic effects through allosteric enhancement of the effects of the inhibitory neurotransmitter GABA at the GABA(A) receptor. Indipl... |