克拉利宾
克拉利宾结构式
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常用名 | 克拉利宾 | 英文名 | Cladribine |
|---|---|---|---|---|
| CAS号 | 4291-63-8 | 分子量 | 285.687 | |
| 密度 | 2.0±0.1 g/cm3 | 沸点 | 547.6±60.0 °C at 760 mmHg | |
| 分子式 | C10H12ClN5O3 | 熔点 | 181-185 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 285.0±32.9 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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The potential of clofarabine in MLL-rearranged infant acute lymphoblastic leukaemia.
Eur. J. Cancer 51 , 2008-21, (2015) MLL-rearranged acute lymphoblastic leukaemia (ALL) in infants is the most difficult-to-treat type of childhood ALL, displaying a chemotherapy-resistant phenotype, and unique histone modifications, gene expression signatures and DNA methylation patterns. MLL-r... |
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Preclinical examination of clofarabine in pediatric ependymoma: intratumoral concentrations insufficient to warrant further study.
Cancer Chemother. Pharmacol. 75 , 897-906, (2015) Clofarabine, a deoxyadenosine analog, was an active anticancer drug in our in vitro high-throughput screening against mouse ependymoma neurospheres. To characterize the clofarabine disposition in mice for further preclinical efficacy studies, we evaluated the... |
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Cladribine in the treatment of acute myeloid leukemia.
Leuk. Res. 38(4) , 425-7, (2014)
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Cladribine, cytarabine, filgrastim, and mitoxantrone (CLAG-M) compared to standard induction in acute myeloid leukemia from myelodysplastic syndrome after azanucleoside failure
Leuk. Res. 38(4) , 443-6, (2014) For patients with acute myeloid leukemia from antecedent myelodysplastic syndrome particularly after azanucleoside treatment failure, outcome is poor. Here, we conducted a case-control study in these patients to compare the efficacy of CLAG-M induction (28 pa... |
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Phase II, multicenter, randomized trial of CPX-351 (cytarabine:daunorubicin) liposome injection versus intensive salvage therapy in adults with first relapse AML.
Cancer 121(2) , 234-42, (2015) CPX-351 is a liposome-encapsulated fixed-molar-ratio formulation of cytarabine and daunorubicin that exploits molar ratio-dependent drug-drug synergy to enhance antileukemic efficacy.This phase II study randomized 125 patients 2:1 to CPX-351 or investigators'... |
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Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia.
Br. J. Haematol. 168(3) , 371-83, (2015) Natural killer (NK) large granular lymphocyte (LGL) leukaemia features a clonal proliferation of CD3(-) NK cells that can be classified into either aggressive or chronic categories. The NKL cell line, derived from an aggressive Asian NK cell leukaemia, and pa... |
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[Systemic mastocytosis].
Dtsch. Med. Wochenschr. 139(31-32) , 1572-5, (2014)
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Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia.
J. Clin. Oncol. 31(19) , e300-3, (2013)
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Cladribine interferes with IL-1β synaptic effects in experimental multiple sclerosis
J. Neuroimmunol. 264(1-2) , 8-13, (2013) Alterations of glutamate-mediated synaptic transmission occur in both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), the animal model of MS. Here we investigated whether intracerebroventricular (Icv) administration of cladribine ... |
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Mycoplasma hyorhinis-encoded purine nucleoside phosphorylase: kinetic properties and its effect on the cytostatic potential of purine-based anticancer drugs.
Mol. Pharmacol. 84(6) , 865-75, (2013) A mycoplasma-encoded purine nucleoside phosphorylase (designated PNPHyor) has been cloned and characterized for the first time. Efficient phosphorolysis of natural 6-oxopurine and 6-aminopurine nucleosides was observed, with adenosine the preferred natural su... |