5-甲基尿嘧啶
5-甲基尿嘧啶结构式
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常用名 | 5-甲基尿嘧啶 | 英文名 | 5-Methylurapidil |
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| CAS号 | 34661-85-3 | 分子量 | 437.96300 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C21H32ClN5O3 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Cell membrane chromatography competitive binding analysis for characterization of α1A adrenoreceptor binding interactions.
Anal. Bioanal. Chem 400(10) , 3625-33, (2011) A new high α(1A) adrenoreceptor (α(1A)AR) expression cell membrane chromatography (CMC) method was developed for characterization of α(1A)AR binding interactions. HEK293 α(1A) cell line, which expresses stably high levels of α(1A)AR, was used to prepare the s... |
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Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats.
Auton. Autacoid Pharmacol. 29(1-2) , 25-31, (2009) 1 Increased renal vascular resistance is one renal functional abnormality that contributes to hypertension, and alpha(1)-adrenoceptors play a pivotal role in modulating this renal vascular resistance. This study investigates the functional contribution of alp... |
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Alpha-1A adrenergic receptor activation increases inhibitory tone in CA1 hippocampus.
Epilepsy Res. 84(2-3) , 97-109, (2009) The endogenous catecholamine norepinephrine (NE) exhibits anti-epileptic properties, however it is not well understood which adrenergic receptor (AR) mediates this effect. The aim of this study was to investigate alpha(1)-adrenergic receptor activation in reg... |
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Pharmacological characterization of alpha1- and beta-adrenergic synergism of 5'DII activity in rat brown adipocytes.
Arch. Physiol. Biochem. 112(1) , 23-30, (2006) The role of adrenoceptor subtypes was studied in rat brown adipose tissue (BAT). The type II 5'-deiodinase (5'DII) was activated in response to simultaneous stimulation by beta3- and alpha1-adrenergic agonists, BRL 37344 or CGP 12177, and cirazoline, in brown... |
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Influence of cisplatin-induced renal failure on the alpha(1)-adrenoceptor subtype causing vasoconstriction in the kidney of the rat.
Eur. J. Pharmacol. 569(1-2) , 110-8, (2007) This study investigated whether the alpha(1)-adrenoceptor subtype(s) mediating the vasoconstrictor actions of the renal sympathetic nerves were altered in rats with cisplatin-induced renal failure. Male Wistar Kyoto rats were used and half received cisplatin ... |
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A comparative in vitro study to determine the beneficial effect of calcium-channel and alpha(1)-adrenoceptor antagonism on human ureteric activity.
BJU Int. 98(3) , 651-5, (2006) To compare the in vitro human ureteric muscle response to calcium-channel and alpha-adrenoceptor antagonists, to determine the promoting factor for stone passage. Clinical trials suggest that stone passage in renal colic can be promoted by ureteric relaxation... |
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The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism.
Mol. Pharmacol. 74(4) , 1000-7, (2008) Activation of the endogenous alpha1-adrenergic receptor (AR) associated with human aortic smooth muscle cells resulted in a dose- and time-dependent increase in the levels of mitochondrial reactive oxygen species (ROS). ROS increases were apparent within 10 m... |
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Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension.
Acta Pharmacol. Sin. 29(5) , 564-72, (2008) This study investigates the subtypes of the alpha1-adrenoceptor mediating the adrenergically-induced renal vasoconstrictor responses in streptozotocin-induced diabetic and non-diabetic 2-kidney one clip (2K1C) Goldblatt hypertensive rats.The renal blood flow ... |
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Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus.
J. Pharmacol. Exp. Ther. 321(3) , 1062-8, (2007) The importance of adrenergic receptors (ARs) in the hippocampus has generally focused on betaARs; however, interest is growing in hippocampal alphaARs given their purported neuroprotective role. We have previously reported alpha(1)AR transcripts in a subpopul... |
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Transient allodynia pain models in mice for early assessment of analgesic activity.
Br. J. Pharmacol. 153(4) , 769-74, (2008) The most common preclinical models of neuropathic pain involve surgical ligation of sensory nerves, which is especially difficult in mice. Transient models of chemically sensitized allodynia are potentially useful for rapidly characterizing the analgesic prof... |