除草醚
除草醚结构式
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常用名 | 除草醚 | 英文名 | nitrofen |
|---|---|---|---|---|
| CAS号 | 1836-75-5 | 分子量 | 284.095 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 360.6±32.0 °C at 760 mmHg | |
| 分子式 | C12H7Cl2NO3 | 熔点 | 69-70°C | |
| MSDS | 中文版 美版 | 闪点 | 171.9±25.1 °C | |
| 符号 |
GHS07, GHS08, GHS09 |
信号词 | Danger |
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Myogenin gene expression is not altered in the developing diaphragm of nitrofen-induced congenital diaphragmatic hernia.
Pediatr. Surg. Int. 30(9) , 901-6, (2014) Pleuroperitoneal folds (PPFs) represent the only source of muscle precursors cells (MPCs) in the primordial diaphragm. However, the exact pathogenesis of malformed PPFs and congenital diaphragmatic hernia (CDH) remains unclear. The muscle-specific transcripti... |
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Prevention of pulmonary hypoplasia and pulmonary vascular remodeling by antenatal simvastatin treatment in nitrofen-induced congenital diaphragmatic hernia.
Am. J. Physiol. Lung Cell. Mol. Physiol. 308(7) , L672-82, (2015) Congenital diaphragmatic hernia (CDH) has a high mortality rate mainly due to lung hypoplasia and persistent pulmonary hypertension of the newborn (PPHN). Simvastatin has been shown to prevent the development of pulmonary hypertension (PH) in experimental mod... |
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Prenatal administration of all-trans retinoic acid upregulates leptin signaling in hypoplastic rat lungs with experimental congenital diaphragmatic hernia.
Pediatr. Surg. Int. 30(12) , 1183-90, (2014) Pulmonary hypoplasia (PH), characterized by alveolar immaturity, is one of the leading causes of respiratory insufficiency in newborns with congenital diaphragmatic hernia (CDH). Leptin (Lep) and its receptor (Lep-R) play an important role in fetal lung growt... |
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Disruption of copper-dependent signaling pathway in the nitrofen-induced congenital diaphragmatic hernia.
Pediatr. Surg. Int. 31(1) , 31-5, (2015) Normal development of the fetal diaphragm requires muscularization of the diaphragm as well as the structural integrity of its underlying connective tissue components. Developmental mutations that inhibit the formation of extracellular matrix (ECM) have been ... |
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Defective pulmonary innervation and autonomic imbalance in congenital diaphragmatic hernia.
Am. J. Physiol. Lung Cell. Mol. Physiol. 302(4) , L390-8, (2012) Congenital diaphragmatic hernia (CDH) is associated with significant mortality due to lung hypoplasia and pulmonary hypertension. The role of embryonic pulmonary innervation in normal lung development and lung maldevelopment in CDH has not been defined. We hy... |
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Prenatal administration of retinoic acid upregulates connective tissue growth factor in the nitrofen CDH model.
Pediatr. Surg. Int. 27(6) , 573-7, (2011) Recent studies have suggested that retinoids may be involved in the molecular mechanisms of pulmonary hypoplasia (PH) in congenital diaphragmatic hernia (CDH). Connective tissue growth factor (CTGF) plays a key role in foetal lung development and remodelling ... |
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Comparison of nitrofen uptake via water and food and its distribution in tissue of common carp, Cyprinus carpio L.
Bull. Environ. Contam. Toxicol. 87(3) , 287-91, (2011) Carp (Cyprinus carpio L.) were exposed to nitrofen (NIP) by different routes (via water or food) to compare bioaccumulation parameters and tissue distribution. The bioconcentration factor of NIP was 5,100, and the lipid-corrected biomagnification factor was 0... |
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Pax3gene expression is not altered during diaphragmatic development in nitrofen-induced congenital diaphragmatic hernia
J. Pediatr. Surg. 47(6) , 1067-71, (2012) Background/Purpose Malformations of the pleuroperitoneal folds (PPFs) have been identified as the origin of the diaphragmatic defect in congenital diaphragmatic hernia (CDH). Pax3, expressed in muscle precursor cells (MPCs), plays a key role in regulating myo... |
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Nitrofen interferes with trophoblastic expression of retinol-binding protein and transthyretin during lung morphogenesis in the nitrofen-induced congenital diaphragmatic hernia model.
Pediatr. Surg. Int. 28(2) , 143-8, (2012) Retinoids play a key role in lung development. Retinoid signaling pathway has been shown to be disrupted in the nitrofen model of congenital diaphragmatic hernia (CDH) but the exact mechanism is not clearly understood. Retinol-binding protein (RBP) and transt... |
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The embryology of the diaphragm.
Semin. Pediatr. Surg. 20(3) , 161-9, (2011) Despite the progress in prenatal diagnosis and intervention as well as postnatal therapeutic strategies, congenital diaphragmatic hernia (CDH) is still associated with a meaningful mortality because of the induced pulmonary hypoplasia. An essential key in und... |