Ebelactone A
Ebelactone A结构式
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常用名 | Ebelactone A | 英文名 | Ebelactone A |
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| CAS号 | 76808-16-7 | 分子量 | 338.48200 | |
| 密度 | 1.011g/cm3 | 沸点 | 462.8ºC at 760 mmHg | |
| 分子式 | C20H34O4 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 152.8ºC |
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Structural studies on ebelactone A and B, esterase inhibitors produced by actinomycetes.
J. Antibiot. 35 , 1495-1499, (1982)
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Biosynthetic studies of ebelactone A and B by 13C NMR spectrometry.
J. Antibiot. 35 , 1670, (1982) Biosynthetic pathways of ebelactone A and B were studied by 13C NMR spectroscopy. By using 13C labeled compounds as precursors it was determined that ebelactone A was derived from one molecule of acetic acid and six propionic acids and ebelactone B from one m... |
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Effects of ebelactone B, a lipase inhibitor, on intestinal fat absorption in the rat.
J. Enzym. Inhib. 10(1) , 57-63, (1996) Ebelactones A and B, natural products from Streptomyces aburaviensis are potent inhibitors of pancreatic lipase. Lipase is the key enzyme required for the absorption of dietary triglycerides (TG). Ebelactone B inhibited, in a dose-dependent manner, the intest... |
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β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents.
J. Antibiot. 64(7) , 483-7, (2011) Homoserine transacetylase (HTA) catalyzes the transfer of an acetyl group from acetyl-CoA to the hydroxyl group of homoserine. This is the first committed step in the biosynthesis of methionine (Met) from aspartic acid in many fungi, Gram-positive and some Gr... |
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Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme.
J. Biol. Chem. 267 , 3811-3818, (1992) Acylpeptide hydrolase may be involved in N-terminal deacetylation of nascent polypeptide chains and of bioactive peptides. The activity of this enzyme from human erythrocytes is sensitive to anions such as chloride, nitrate, and fluoride. Furthermore, blocked... |
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Human acylpeptide hydrolase. Studies on its thiol groups and mechanism of action.
J. Biol. Chem. 269(21) , 15076-84, (1994) The presence of a cysteine residue(s) near the active site of acylpeptide hydrolase was suggested by inactivation of the enzyme with sulfhydryl-modifying agents and by the substantial protection against inactivation afforded by the competitive inhibitor acety... |
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Stereocontrolled total synthesis of (-)-ebelactone A.
Org. Lett. 4(12) , 2043-5, (2002) [structure: see text] The highly stereocontrolled hydroboration of an alkene, a subsequent Suzuki-Miyaura cross-coupling reaction, a silylcupration on a nonterminal acetylene, and an iododesilylation were the key steps in a convergent total synthesis of (-)-e... |
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Low-molecular-weight immunomodifiers produced by micro-organisms.
Biotechnol. Genet. Eng. Rev. 3 , 255-73, (1985)
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Purification and properties of an esterase from human breast cyst fluid.
Cancer Res. 51(4) , 1092-8, (1991) Levels of estradiol 17 beta-ester hydrolytic activity in the breast cyst fluid (BCF) from 25 different women with fibrocystic disease of the breast were found to vary over a wide range (0-2.4 nmol/min/mg protein for estradiol acetate). On the basis of electro... |
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Studies on low-molecular-weight immunomodifiers produced by microorganisms: results of ten years' effort.
Rev. Infect. Dis. 6(3) , 412-20, (1984) The screening for low-molecular-weight enzyme inhibitors produced by microorganisms was initiated in 1966, and by 1972 inhibitors of various proteases had been discovered. At that time the study of enzyme inhibitors was expanded to include the search for low-... |