苯并噻吩-2-硼酸
苯并噻吩-2-硼酸结构式
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常用名 | 苯并噻吩-2-硼酸 | 英文名 | 1-Benzothiophen-2-ylboronic acid |
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| CAS号 | 98437-23-1 | 分子量 | 178.016 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 390.2±34.0 °C at 760 mmHg | |
| 分子式 | C8H7BO2S | 熔点 | 254-256 °C | |
| MSDS | 中文版 美版 | 闪点 | 189.8±25.7 °C |
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Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.
J. Med. Chem. 51 , 7057-7060, (2008) A series of commercial phenyl-, heteroaryl-, alkyl-, and alkenylboronic acids were evaluated for their FAAH and MGL inhibitory activities. The compounds were generally selective for FAAH, with IC50 in the nanomolar or low-micromolar range. Eight of these comp... |
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Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.
J. Med. Chem. 52 , 6097-106, (2009) Penicillin binding proteins (PBPs) catalyze steps in the biosynthesis of bacterial cell walls and are the targets for the beta-lactam antibiotics. Non-beta-lactam based antibiotics that target PBPs are of interest because bacteria have evolved resistance to t... |
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Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy.
J. Med. Chem. 50 , 5644, (2007) Benzo[b]thiophene-2-ylboronic acid, 1, is a 27 nM inhibitor of the class C beta-lactamase AmpC and potentiates the activity of beta-lactam antibiotics in bacteria that express this and related enzymes. As is often true, the potency of compound 1 against the e... |