氯烯
氯烯结构式
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常用名 | 氯烯 | 英文名 | Cloricromenehydrochloride |
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| CAS号 | 74697-28-2 | 分子量 | 432.33800 | |
| 密度 | N/A | 沸点 | 538ºC at 760 mmHg | |
| 分子式 | C20H27Cl2NO5 | 熔点 | 221-222.3ºC | |
| MSDS | 美版 | 闪点 | 279.2ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Cloricromene in endotoxemia: role of NF-kappaB.
Naunyn Schmiedebergs Arch. Pharmacol. 370(2) , 140-5, (2004) In this study we investigated, for the first time in vivo, the effect of cloricromene, a cumarine derivative, on NF-kappaB activation in endotoxin-treated rats. Endotoxemia was induced in male rats by the intravenous injection of Salmonella typhosa lipopolysa... |
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Tumor necrosis factor induces E-selectin production in splanchnic artery occlusion shock.
Am. J. Physiol. 268(4 Pt 2) , H1412-7, (1995) Splanchnic arteries were clamped for 45 min to induce splanchnic artery occlusion (SAO) shock in anesthetized rats. Sham-operated animals were used as controls. Survival time, serum tumor necrosis factor-alpha (TNF-alpha), white blood cell (WBC) count, mean a... |
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Preparation and characterization of eudragit retard nanosuspensions for the ocular delivery of cloricromene.
AAPS PharmSciTech 7(1) , E27, (2006) The purpose of this study was to improve the stability of cloricromene (AD6) in ophthalmic formulations and its drug availability at the ocular level. To this end, AD6-loaded polymeric nanoparticle suspensions were made using inert polymer resins (Eudragit RS... |
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Enhancement of availability of cloricromene at brain level by a lipophilic prodrug.
J. Pharm. Pharmacol. 58(7) , 1001-5, (2006) The pharmacokinetics of a lipophilic alkylamino acid (LAA) prodrug of cloricromene (AD6), name CLOR-C4, was studied in rat plasma and brain. In particular, we observed that the intraperitoneal administration of CLOR-C4 to rats was able to provide a slight but... |
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Cloricromene, a coumarine derivative, reduced the development of periodontitis in rats.
Naunyn Schmiedebergs Arch. Pharmacol. 373(1) , 51-9, (2006) Recent studies have demonstrated that cloricromene, a coumarin derivative, exerts protective effects in models of inflammation and shock. Tumour necrosis factor plays a pivotal role in the induction of genes involved in physiological processes, as well as in ... |
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Effect of cloricromene on intermittent claudication. A randomized, double-blind, placebo-controlled trial in patients treated with aspirin: effect on claudication distance and quality of life. CRAMPS Investigator Group. Cloricromene Randomized Arteriopathy Multicenter Prospective Study.
Vasc. Med. 5(2) , 83-9, (2000) The main aim of medical treatment for intermittent claudication (IC) is the reduction of mortality and morbidity from ischemic cardiovascular disease. However, symptomatic treatment with the aim of improving exercise performance and the overall quality of lif... |
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Retinal and systemic pharmacokinetics of the anti-inflammatory drug cloricromene following oral administration in the rat and rabbit.
J. Ocul. Pharmacol. Ther. 23(3) , 257-63, (2007) The aim of this study was to evaluate the retina and plasma distribution of cloricromene, a coumarin derivative, and its active metabolite (MET) after an oral administration in rabbits and rats.A single dose of cloricromene was orally administered to rabbits ... |
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Effects of cloricromene on the levels of endothelin and on the microcirculatory function in peripheral atherosclerotic arteriopathies.
Pharmacology 52(1) , 8-15, (1996) The effects of cloricromene on plasma endothelin-1 (ET-1) levels and on microcirculatory function in 9 patients with peripheral atherosclerotic arteriopathy (PAA) and in healthy control subjects were studied. ET-1 levels and microcirculatory function were eva... |
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Intradermal injection vs. oral treatment of tinnitus.
Therapie. 56(4) , 403-7, (2001) Local pharmacological intradermal infiltration is a therapy being used more and more thanks to the positive results achieved, particularly for all those therapies acting on the microcirculation. In trying to better the results obtained with medical therapy fo... |
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Protective effects of a coumarin derivative in diabetic rats.
Invest. Ophthalmol. Vis. Sci. 50(8) , 3846-52, (2009) Retinal microvascular cells play a crucial role in the pathogenesis of diabetic retinopathy. The endothelial effects of cloricromene, a novel coumarin derivative, on diabetic retinopathy induced by streptozotocin (STZ) in the rat were investigated.Cloricromen... |