4-氨基苯甲酸丁酯
4-氨基苯甲酸丁酯结构式
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常用名 | 4-氨基苯甲酸丁酯 | 英文名 | butamben |
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| CAS号 | 94-25-7 | 分子量 | 193.242 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 325.7±0.0 °C at 760 mmHg | |
| 分子式 | C11H15NO2 | 熔点 | 57-58 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 184.6±17.9 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Inhibition of sensory neuronal TRPs contributes to anti-nociception by butamben.
Neurosci. Lett. 506(2) , 297-302, (2012) Butamben (n-butyl-p-aminobenzoic acid) is a pain-relieving local anesthetic for topical use. Blockade of voltage-gated channel expressed in the peripheral sensory neurons has been suggested as a mechanism of action. Its effects on another sensory neuronal cha... |
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Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression.
Bioorg. Med. Chem. Lett. 21 , 7363-6, (2011) As the primary step for 'drug repositioning', we evaluated the effect of 2000 drugs and drug candidates on the commitment of bi-potential mesenchymal precursor C2C12 cells into osteoblasts in the presence of bone morphogenetic protein (BMP)-2 and found that b... |
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Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors.
J. Biol. Chem. 277(46) , 43691-7, (2002) The Xenopus benzoate nuclear hormone receptors, BXRalpha and BXRbeta, share 82% identity within their ligand-binding domains and are classified as members of the NR1I2 subfamily that includes the mammalian steroid and xenobiotic receptor, SXR/PXR. Although al... |
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Nerve blocks with 5% butamben suspension for the treatment of chronic pain syndromes.
Reg. Anesth. Pain Med. 23(4) , 395-401, (1998) Butamben is a non-water-soluble local anesthetic that can be prepared as an aqueous suspension for nerve blocks. This report describes the use of 5% butamben suspension for the treatment of chronic pain of cancer and noncancer origin.The clinical courses of 7... |
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Analgesic synergy between topical morphine and butamben in mice.
Anesth. Analg. 97(4) , 1103-7, table of contents, (2003) Studies have revealed that lidocaine is an effective analgesic when applied topically to the tail of a mouse in the radiant heat tail-flick assay. In addition, the topical combination of lidocaine with morphine revealed synergistic interactions between the tw... |
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Identification of a yellow impurity in aged samples of aqueous butamben suspension: evidence for the oxidative degradation of poly(ethylene glycol).
J. Pharm. Sci. 89(6) , 766-70, (2000) Butamben (butyl p-aminobenzoate) has been formulated to provide long-acting treatment for chronic pain. The suspension, which contains poly(ethylene glycol) and polysorbate 80, was found to yellow under ambient conditions if not adequately protected from oxyg... |
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The antinociceptive and histologic effect of sciatic nerve blocks with 5% butamben suspension in rats.
Anesth. Analg. 94(3) , 711-6; table of contents, (2002) Butamben, a lipophilic local anesthetic of the ester class, produces a differential nerve block of long duration. Epidural and peripheral nerve blocks with butamben, formulated as a 5%--10% suspension, result in prolonged analgesia without significant motor b... |
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Comparison of epidural butamben to celiac plexus neurolytic block for the treatment of the pain of pancreatic cancer.
Clin. J. Pain 16(4) , 304-9, (2000) To compare pain relief in metastatic pancreatic cancer patients between neurolytic celiac plexus block (NCPB) and epidural 5% butamben suspension (EBS), a material-based delivery system of a local anesthetic that produces a long-lasting differential nerve blo... |
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Particle size determination of a flocculated suspension using a light-scattering particle size analyzer.
Drug Dev. Ind. Pharm. 24(11) , 1089-93, (1998) Microscopy is a useful and direct method for measuring the particle size of a suspension because, in addition to the particle size and size distribution, it provides visual detection of the shape and state of aggregation of the particles in the suspension. Ho... |
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Analgesic efficacy of topical butamben picrate.
J. Am. Podiatr. Med. Assoc. 85(12) , 738-40, (1995) Over the past generation, advents in topical antibiotics and oral analgesia have obscured butamen and its family of topical anesthetics. Using a modified version of the McGill University pain questionnaire, this study attempts to establish the efficacy and cl... |