布帕伐醌
布帕伐醌结构式
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常用名 | 布帕伐醌 | 英文名 | Buparvaquone |
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| CAS号 | 88426-33-9 | 分子量 | 326.429 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 460.7±45.0 °C at 760 mmHg | |
| 分子式 | C21H26O3 | 熔点 | 178-184ºC | |
| MSDS | 中文版 美版 | 闪点 | 246.5±25.2 °C |
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Drug delivery systems for the topical treatment of cutaneous leishmaniasis.
Expert Opin. Drug Deliv. 9(9) , 1083-97, (2012) The parenteral administration of pentavalent antimonials for the treatment of all forms of leishmaniasis, including cutaneous leishamniasis (CL), has several limitations. Therapy is long, requiring repeated doses and the adverse reactions are frequent. Topica... |
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In-vivo therapeutic efficacy trial with artemisinin derivative, buparvaquone and imidocarb dipropionate against Babesia equi infection in donkeys.
J. Vet. Med. Sci. 65(11) , 1171-7, (2003) The therapeutic efficacy of imidocarb, artesunate, arteether, buparvaquone and arteether+buparvaquone combination was evaluated against Babesia equi of Indian origin in splenectomised donkeys with experimentally induced acute infection. Efficacies of these dr... |
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Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone.
Eur. J. Pharm. Sci. 23(2) , 151-8, (2004) Novel water-soluble phosphate prodrugs (2b-5b) of buparvaquone-oxime (1a) and buparvaquone-O-methyloxime (1b) were synthesized and evaluated in vitro as potential oral prodrugs against leishmaniasis. Buparvaquone-oxime (1a), and most probably also buparvaquon... |
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The protozoan parasite Theileria annulata alters the differentiation state of the infected macrophage and suppresses musculoaponeurotic fibrosarcoma oncogene (MAF) transcription factors.
Int. J. Parasitol. 39(10) , 1099-108, (2009) The tick-borne protozoan parasite Theileria annulata causes a debilitating disease of cattle called Tropical Theileriosis. The parasite predominantly invades bovine macrophages (m phi) and induces host cell transformation by a mechanism that has not been full... |
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Clinical efficacy and plasma concentrations of two formulations of buparvaquone in cattle infected with East Coast fever (Theileria parva infection).
Res. Vet. Sci. 81(1) , 119-26, (2006) East Coast fever, caused by the protozoan parasite Theileria parva, kills about 600,000 cattle annually in Africa. The hydroxynaphthoquinone compound buparvaquone (BPQ) is curative. Sixteen calves were infected with T. parva. On manifestation of disease sympt... |
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Apoptosis of Theileria-infected lymphocytes induced upon parasite death involves activation of caspases 9 and 3.
Biochimie 85(8) , 771-6, (2003) The intracellular parasite Theileria parva (T. parva) can infect bovine B and T-lymphocytes. T. parva-infected cells become transformed, and they survive and proliferate independently of exogenous growth factors. In vivo the uncontrolled cellular proliferatio... |
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Cerebral theileriosis in a Holstein calf.
Vet. Rec. 154(17) , 533-4, (2004)
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Topical buparvaquone formulations for the treatment of cutaneous leishmaniasis.
J. Pharm. Pharmacol. 59(1) , 41-9, (2007) As the part of a study to develop buparvaquone (BPQ) formulations for the treatment of cutaneous leishmaniasis, the topical delivery of BPQ and one of its prodrugs from a range of formulations was evaluated. In previous studies, BPQ and its prodrugs were show... |
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Optimization and validation of RP-HPLC-UV method with solid-phase extraction for determination of buparvaquone in human and rabbit plasma: application to pharmacokinetic study.
Biomed. Chromatogr. 22(5) , 535-41, (2008) A simple, sensitive and specific reversed-phase high-performance liquid chromatographic method with UV detection at 251 nm was developed for quantitation of buparvaquone (BPQ) in human and rabbit plasma. The method utilizes 250 microL of plasma and sample pre... |
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Evaluation and structure-activity relationship study of acute toxicity of naphthoquinones to Photobacterium phosphoreum, Photobacterium T3B.
Bull. Environ. Contam. Toxicol. 85(2) , 116-20, (2010) The acute toxicities of five naphthoquinone compounds to Photobacterium phosphoreum were determined. We evaluated the mechanism of toxicity using the structure-activity relationship technique. The results showed that some factors, including the species of sub... |