兰雪醌
兰雪醌结构式
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常用名 | 兰雪醌 | 英文名 | Plumbagin |
|---|---|---|---|---|
| CAS号 | 481-42-5 | 分子量 | 188.17900 | |
| 密度 | 1.354g/cm3 | 沸点 | 383.9ºC at 760 mmHg | |
| 分子式 | C11H8O3 | 熔点 | 76-78ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 200.2ºC | |
| 符号 |
GHS05, GHS06 |
信号词 | Danger |
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Antitumorigenic effect of plumbagin by induction of SH2-containing protein tyrosine phosphatase 1 in human gastric cancer cells.
Int. J. Oncol. 46 , 2380-8, (2015) A recent study reported that plumbagin downregulated the activity of Janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) pathway to show various antitumor effects in multiple myeloma cells. We aimed in this in vitro study to demon... |
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Binding and Anticancer Properties of Plumbagin with Human Serum Albumin.
Chem. Biol. Drug Des. 86 , 362-9, (2015) Plumbagin has received extensive attention as a promising anticancer drug. Therefore, we investigated the binding and anticancer properties of plumbagin with human serum albumin. Fluorescence results demonstrated that plumbagin interacts with human serum albu... |
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Inhibition of ANO1/TMEM16A Chloride Channel by Idebenone and Its Cytotoxicity to Cancer Cell Lines.
PLoS ONE 10 , e0133656, (2015) The expression levels of anoctamin 1 (ANO1, TMEM16A), a calcium-activated chloride channel (CaCC), are significantly increased in several tumors, and inhibition of ANO1 is known to reduce cell proliferation and migration. Here, we performed cell-based screeni... |
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Posttranslational Regulation of Human DNA Polymerase ι.
J. Biol. Chem. 290 , 27332-44, (2015) Human DNA polymerases (pols) η and ι are Y-family DNA polymerase paralogs that facilitate translesion synthesis past damaged DNA. Both polη and polι can be monoubiquitinated in vivo. Polη has been shown to be ubiquitinated at one primary site. When this site ... |
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NADPH oxidase 4 is involved in the triethylene glycol dimethacrylate-induced reactive oxygen species and apoptosis in human embryonic palatal mesenchymal and dental pulp cells.
Clin. Oral Investig. 19 , 1463-71, (2015) Triethylene glycol dimethacrylate (TEGDMA) is a common component of resin-based dental composites and endodontic sealers. TEGDMA induces apoptosis in several types of cells. However, the mechanisms are not completely understood. The aim of this study was to i... |
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Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production.
Int. J. Clin. Exp. Pathol. 8 , 13695-706, (2016) Apoptosis of osteoblasts caused by glucocorticoids has been identified as an important contributor to the development of osteoporosis. Tanshinone IIA (Tan), an active ingredient extracted from the rhizome of the Salvia miltiorrhiza Bunge (Danshen), has been r... |
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Plumbagin alters telomere dynamics, induces DNA damage and cell death in human brain tumour cells.
Mutat. Res. Genet. Toxicol. Environ. Mutagen. 793 , 86-95, (2015) Natural plant products may possess much potential in palliative therapy and supportive strategies of current cancer treatments with lesser cytotoxicity to normal cells compared to conventional chemotherapy. In the current study, anti-cancer properties of plum... |
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Plumbagin reduces human colon cancer cell survival by inducing cell cycle arrest and mitochondria-mediated apoptosis.
Int. J. Oncol. 45(5) , 1913-20, (2014) Despite increased use of early detection methods and more aggressive treatment strategies, the worldwide incidence of colorectal cancer is still on the rise. Consequently, it remains urgent to identify novel agents with enhanced efficacy in prevention and/or ... |
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The role of thioredoxin reductase and glutathione reductase in plumbagin-induced, reactive oxygen species-mediated apoptosis in cancer cell lines.
Eur. J. Pharmacol. 765 , 384-93, (2015) Plumbagin is a secondary metabolite that was first identified in the Plumbago genus of plants. It is a naphthoquinone compound with anti-atherosclerosis, anticancer, anti-inflammatory, antimicrobial, contraceptive, cardiotonic, immunosuppressive, and neuropro... |
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Naphthoquinone-mediated inhibition of lysine acetyltransferase KAT3B/p300, basis for non-toxic inhibitor synthesis.
J. Biol. Chem. , (2014) Hydroxynaphthoquinone-based inhibitors of the lysine acetyltransferase KAT3B (p300), such as plumbagin, are relatively toxic. Here, we report that free thiol reactivity and redox cycling properties greatly contribute to the toxicity of plumbagin. A reactive 3... |