Bisindolylmaleimide I
Bisindolylmaleimide I结构式
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常用名 | Bisindolylmaleimide I | 英文名 | Bisindolylmaleimide I (GF109203X) |
|---|---|---|---|---|
| CAS号 | 133052-90-1 | 分子量 | 412.484 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 685.6±55.0 °C at 760 mmHg | |
| 分子式 | C25H24N4O2 | 熔点 | 208-210ºC | |
| MSDS | 美版 | 闪点 | 368.5±31.5 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Warning |
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Tumour suppressor TRIM33 targets nuclear β-catenin degradation.
Nat. Commun. 6 , 6156, (2015) Aberrant activation of β-catenin in the nucleus has been implicated in a variety of human cancers, but the fate of nuclear β-catenin is unknown. Here we demonstrate that the tripartite motif-containing protein 33 (TRIM33), acting as an E3 ubiquitin ligase, re... |
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Role of SM22 in the differential regulation of phasic vs. tonic smooth muscle.
Am. J. Physiol. Gastrointest. Liver Physiol. 308(7) , G605-12, (2015) Preliminary proteomics studies between tonic vs. phasic smooth muscles identified three distinct protein spots identified to be those of transgelin (SM22). The latter was found to be distinctly downregulated in the internal anal sphincter (IAS) vs. rectal smo... |
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Excitation of rat sympathetic neurons via M1 muscarinic receptors independently of Kv7 channels.
Pflugers Arch. 466(12) , 2289-303, (2014) The slow cholinergic transmission in autonomic ganglia is known to be mediated by an inhibition of Kv7 channels via M1 muscarinic acetylcholine receptors. However, in the present experiments using primary cultures of rat superior cervical ganglion neurons, th... |
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Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance.
Cancer Lett. 361(1) , 112-20, (2015) Although triapine is promising for treatment of advanced leukemia, it failed against solid tumors due to widely unknown reasons. To address this issue, a new triapine-resistant cell line (SW480/tria) was generated by drug selection and investigated in this st... |
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Endothelin-1 protects human melanocytes from UV-induced DNA damage by activating JNK and p38 signalling pathways.
Exp. Dermatol. 24(4) , 269-74, (2015) Endothelin-1 is a paracrine factor with mitogenic, melanogenic and survival effects on cultured human melanocytes. We report that endothelin-1 signalling reduced the generation and enhanced the repair of ultraviolet radiation (UV)-induced DNA photoproducts, a... |
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Tight junction disruption by cadmium in an in vitro human airway tissue model.
Respir. Res. 16 , 30, (2015) The cadmium (Cd) present in air pollutants and cigarette smoke has the potential of causing multiple adverse health outcomes involving damage to pulmonary and cardiovascular tissue. Injury to pulmonary epithelium may include alterations in tight junction (TJ)... |
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Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation.
Cell Death Dis. 6 , e1750, (2015) Arachidonic acid (AA) is largely released during injury, but it has not been fully studied yet how AA modulates wound repair with stem cells. Therefore, we investigated skin wound-healing effect of AA-stimulated human umbilical cord blood-derived mesenchymal ... |
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Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets.
J. Thromb. Haemost. 12(5) , 748-60, (2014) Rapamycin, an inhibitor of mammalian target of rapamycin complex-1 (mTORC1), reduces platelet spreading, thrombus stability, and clot retraction. Despite an important role of mTORC1 in platelet function, little is known about how it is regulated. The objectiv... |
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Src mediates endocytosis of TWIK-related acid-sensitive K+ 1 channels in PC12 cells in response to nerve growth factor.
Am. J. Physiol. Cell Physiol. 309 , C251-63, (2015) TWIK-related acid-sensitive K(+) (TASK) channels produce background K(+) currents. We elucidated that TASK1 channels in rat adrenal medullary cells and PC12 cells are internalized in a clathrin-dependent manner in response to nerve growth factor (NGF). Here, ... |
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Hypoxia increases pulmonary arterial thromboxane receptor internalization independent of receptor sensitization.
Pulm. Pharmacol. Ther. 30 , 1-10, (2015) Persistent Pulmonary Hypertension of the Newborn (PPHN) is characterized by sustained vasospasm and an increased thromboxane:prostacyclin ratio. Thromboxane (TP) receptors signal via Gαq to mobilize IP3 and Ca(2+), causing pulmonary arterial constriction. We ... |