N-十二烷基吡咯烷酮
N-十二烷基吡咯烷酮结构式
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常用名 | N-十二烷基吡咯烷酮 | 英文名 | Lauryl pyrrolidone |
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| CAS号 | 2687-96-9 | 分子量 | 253.423 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 353.0±0.0 °C at 760 mmHg | |
| 分子式 | C16H31NO | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 152.8±9.9 °C | |
| 符号 |
GHS05, GHS07, GHS09 |
信号词 | Danger |
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In vitro permeation study of hinokitiol: effects of vehicles and enhancers.
Drug Deliv. 15(1) , 19-22, (2008) In vitro permeation of hinokitiol (HKL) through hairless mouse skin was investigated using a diffusion cell. Either propylene glycol (PG) or ethanol (EtOH) was used as a vehicle for HKL. After applying the HKL solutions of 0.5%. 1%, 2%, and 5% onto the skin, ... |
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Electrochemical characterization of liquid phase exfoliated two-dimensional layers of molybdenum disulfide.
ACS Appl. Mater. Interfaces 6(3) , 2125-30, (2014) We report on the electrochemical charge storage behavior of few-layered flakes of molybdenum disulfide (MoS2) obtained by liquid phase exfoliation of bulk MoS2 powder in 1-dodecyl-2-pyrrolidinone. The specific capacitances of the exfoliated flakes obtained us... |
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Aminoborohydrides. 11. Facile reduction of N-alkyl lactams to the corresponding amines using lithium aminoborohydrides.
Org. Lett. 1(5) , 799-801, (1999) [reaction: see text] Various five- and six-membered N-alkyl lactams were reduced to the corresponding cyclic amines using lithium N,N-dialkylaminoborohydrides (LAB). Most of the reductions were essentially complete after refluxing in THF for 2 h. The cyclic a... |
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Design of improved permeation enhancers for transdermal drug delivery.
J. Pharm. Sci. 98(11) , 4085-99, (2009) One promising way to breach the skin's natural barrier to drugs is by the application of chemicals called penetration enhancers. However, identifying potential enhancers is difficult and time consuming. We have developed a virtual screening algorithm for gene... |
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Screening of chemical penetration enhancers for transdermal drug delivery using electrical resistance of skin.
Pharm. Res. 25(11) , 2697-704, (2008) A novel technique is presented for identifying potential chemical penetration enhancers (CPEs) based on changes in the electrical resistance of skin.Specifically, a multi-well resistance chamber was designed and constructed to facilitate more rapid determinat... |
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Comparative studies on the anticonvulsant activity of lipophilic derivatives of gamma-aminobutyric acid and 2-pyrrolidinone in mice.
J. Pharmacobiodyn. 14(1) , 1-8, (1991) Anticonvulsant activity, degradation into gamma-aminobutyric acid (GABA), and concentration in brain of 1-dodecanoyl-2-pyrrolidinone (I), a lipophilic derivative of a lactam of GABA, were compared with those of N-dodecanoyl GABA (II) and 1-dodecyl-2-pyrrolidi... |
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Enhancing effect of combining two pyrrolidone vehicles on transdermal drug delivery.
J. Pharm. Pharmacol. 42(3) , 196-9, (1990) The enhancing effect of combining 1-methyl-2-pyrrolidone (MP) and 1-lauryl-2-pyrrolidone (LP) as the vehicles for transdermal penetration of phenolsulphonphthalein (phenol red) has been investigated by using an in-vitro technique with excised rat skin. LP had... |
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Enhancing effect of N-dodecyl-2-pyrrolidone on the percutaneous absorption of 5-fluorouracil derivatives.
Chem. Pharm. Bull. 46(5) , 831-6, (1998) The enhancing effects of N-dodecyl-2-pyrrolidone (NDP) on the percutaneous absorption of doxifluridine (DOX), 5-fluorouracil (5-FU), tegafur (TEG) and carmofur (CAR) were examined using an in vitro penetration technique and rat skin. Phosphate buffered isoton... |