4-氯-3-乙基苯酚
4-氯-3-乙基苯酚结构式
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常用名 | 4-氯-3-乙基苯酚 | 英文名 | 4-Chloro-3-ethylphenol |
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| CAS号 | 14143-32-9 | 分子量 | 156.609 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 248.1±20.0 °C at 760 mmHg | |
| 分子式 | C8H9ClO | 熔点 | 45-50 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 103.9±21.8 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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The ryanodine receptor agonist 4-chloro-3-ethylphenol blocks ORAI store-operated channels.
Br. J. Pharmacol. 171(5) , 1250-9, (2014) Depletion of the Ca(2+) store by ryanodine receptor (RyR) agonists induces store-operated Ca(2+) entry (SOCE). 4-Chloro-3-ethylphenol (4-CEP) and 4-chloro-m-cresol (4-CmC) are RyR agonists commonly used as research tools and diagnostic reagents for malignant ... |
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Superficial buffer barrier and preferentially directed release of Ca2+ in canine airway smooth muscle.
Am. J. Physiol. 276(5 Pt 1) , L744-53, (1999) We examined cytosolic concentration of Ca2+ ([Ca2+]i) in canine airway smooth muscle using fura 2 fluorimetry (global changes in [Ca2+]i), membrane currents (subsarcolemmal [Ca2+]i), and contractions (deep cytosolic [Ca2+]i). Acetylcholine (10(-4) M) elicited... |
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Actions of 4-chloro-3-ethyl phenol on internal Ca2+ stores in vascular smooth muscle and endothelial cells.
Br. J. Pharmacol. 122(3) , 504-10, (1997) 1. Recently, 4-chloro-3-ethyl phenol (CEP) has been shown to cause the release of internally stored Ca2+ apparently through ryanodine-sensitive Ca2+ channels, in fractionated skeletal muscle terminal cisternae and in a variety of non-excitable cell types. Its... |
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Effects of ryanodine receptor agonist 4-chloro-m-cresol on myoplasmic free Ca2+ concentration and force of contraction in mouse skeletal muscle.
Cell Calcium 24(2) , 105-15, (1998) In single mouse skeletal muscle fibers injected with fluorescent Ca2+ indicator Indo-1, 4-chloro-m-cresol (chlorocresol, 4-CmC) and its lipophilic analogue 4-chloro-3-ethylphenol (4-CEP) increased resting myoplasmic free [Ca2+] ([Ca2+]i) in a dose-dependent m... |
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Dynamic imaging of endoplasmic reticulum Ca2+ concentration in insulin-secreting MIN6 Cells using recombinant targeted cameleons: roles of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2 and ryanodine receptors.
Diabetes 51 Suppl 1 , S190-201, (2002) The endoplasmic reticulum (ER) plays a pivotal role in the regulation of cytosolic Ca(2+) concentrations ([Ca(2+)](cyt)) and hence in insulin secretion from pancreatic beta-cells. However, the molecular mechanisms involved in both the uptake and release of Ca... |
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A ryanodine receptor-like Ca2+ channel is expressed in nonexcitable cells.
Mol. Pharmacol. 47 , 21, (1995) In this study we investigated the effects of 4-chloro-3-ethylphenol on Ca2+ homeostasis, and we report that this compound induces Ca2+ release from a ruthenium red-sensitive Ca2+ release channel present in skeletal muscle terminal cisternae. When tested with ... |
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Mitochondria are fast Ca2+ sinks in rat extraocular muscles: a novel regulatory influence on contractile function and metabolism.
Invest. Ophthalmol. Vis. Sci. 46(12) , 4541-7, (2005) The ultrafast extraocular muscles necessitate tight regulation of free cytosolic Ca2+ concentration ([Ca2+]i). Mitochondrial Ca2+ influx may be fast enough for this role. In the present study, three hypotheses were tested: (1) Mitochondrial Ca2+ uptake regula... |
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Cumulative and bolus in vitro contracture testing with 4-chloro-3-ethylphenol in malignant hyperthermia positive and negative human skeletal muscles.
Anesth. Analg. 101(3) , 710-4, table of contents, (2005) In this study we evaluated the in vitro effects of 4-chloro-3-ethylphenol (CEP) using cumulative (12.5-200 micromol/L) or bolus (75 and 100 micromol/L) administrations, on muscle specimens from malignant hyperthermia (MH) susceptible and MH nonsusceptible pat... |
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Dynamic digital fluorescence ratio imaging of cell calcium in vascular endothelial cells.
Zhongguo Yao Li Xue Bao 20(5) , 385-90, (1999) To study the spatial and temporal distribution of intracellular Ca2+ concentration in cultured bovine pulmonary artery endothelial (BPAE) cells.Cultured BPAE cells were loaded with Fura-2 and observed under an inverted microscope coupled to a microfluorimeter... |
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In vitro effects of 4-chloro-3-ethylphenol in skeletal muscle preparations from malignant hyperthermia susceptible and normal swine.
Eur. J. Anaesthesiol. 19(2) , 135-40, (2002) The in vitro contracture test with halothane and caffeine is the current gold standard for diagnosis of malignant hyperthermia. This test has a sensitivity of 99.0% but a specificity of only 93.6%. Therefore, an alternative drug is desirable which distinguish... |