N-[4-[[1-[2-(6-甲基-2-吡啶基)乙基]-4-哌啶基]羰基]苯基]甲磺酰胺二盐酸盐
![N-[4-[[1-[2-(6-甲基-2-吡啶基)乙基]-4-哌啶基]羰基]苯基]甲磺酰胺二盐酸盐结构式](https://image.chemsrc.com/caspic/420/113559-13-0.png)
N-[4-[[1-[2-(6-甲基-2-吡啶基)乙基]-4-哌啶基]羰基]苯基]甲磺酰胺二盐酸盐结构式
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常用名 | N-[4-[[1-[2-(6-甲基-2-吡啶基)乙基]-4-哌啶基]羰基]苯基]甲磺酰胺二盐酸盐 | 英文名 | E-4031 |
|---|---|---|---|---|
| CAS号 | 113559-13-0 | 分子量 | 474.444 | |
| 密度 | N/A | 沸点 | 561.7ºC at 760 mmHg | |
| 分子式 | C21H29Cl2N3O3S | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 293.5ºC |
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Kcnh2 and Kcnj8 interactively regulate skin wound healing and regeneration.
Wound Repair Regen. 23 , 797-806, (2015) Previous studies indicate that ion channels are mediators of bioelectricity promoting wound closure/regeneration in nonmammalian, lower vertebrate systems. The role of ion channels however in regeneration of wounds in mammalian systems that do not regenerate ... |
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Direct negative chronotropic action of desflurane on sinoatrial node pacemaker activity in the guinea pig heart.
Anesthesiology 120(6) , 1400-13, (2014) Desflurane inhalation is associated with sympathetic activation and concomitant increase in heart rate in humans and experimental animals. There is, however, little information concerning the direct effects of desflurane on electrical activity of sinoatrial n... |
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Bridging Functional and Structural Cardiotoxicity Assays Using Human Embryonic Stem Cell-Derived Cardiomyocytes for a More Comprehensive Risk Assessment.
Toxicol. Sci. 148 , 241-60, (2015) More relevant and reliable preclinical cardiotoxicity tests are required to improve drug safety and reduce the cost of drug development. Current in vitro testing strategies predominantly take the form of functional assays to predict the potential for drug-ind... |
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A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity
Toxicol. Lett. 230(3) , 382-92, (2014) • Current hERG assays remain insensitive as predictors of clinical toxicity. • We have developed a state-of-art computational model of hERG blocking. • The method was validated using two biological assays of functional hERG blocking. • As an example the anti-... |
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Liposomes ameliorate Crizotinib- and Nilotinib-induced inhibition of the cardiac IKr channel and QTc prolongation.
Anticancer Res. 34(9) , 4733-40, (2014) Crizotinib (Xalkori®) and nilotinib (Tasigna®) are tyrosine kinase inhibitors approved for the treatment of non-small cell lung cancer and chronic myeloid leukemia, respectively. Both have been shown to result in electrocardiogram rate-corrected Q-wave T-wave... |
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A Simple Protocol for the Myocardial Differentiation of Human iPS Cells.
Biol. Pharm. Bull. 38 , 1070-5, (2015) We have developed a simple protocol for inducing the myocardial differentiation of human induced pluripotent stem (iPS) cells. Human iPS cell-derived embryonic bodies (EBs) were treated with a combination of activin-A, bone morphogenetic protein-4 and wnt-3a ... |
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Image-based evaluation of contraction-relaxation kinetics of human-induced pluripotent stem cell-derived cardiomyocytes: Correlation and complementarity with extracellular electrophysiology.
J. Mol. Cell. Cardiol. 77 , 178-91, (2014) In this study, we used high-speed video microscopy with motion vector analysis to investigate the contractile characteristics of hiPS-CM monolayer, in addition to further characterizing the motion with extracellular field potential (FP), traction force and th... |
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Atria are More Sensitive Than Ventricles to GS-458967-Induced Inhibition of Late Sodium Current.
J. Cardiovasc. Pharmacol. Ther. 20 , 501-8, (2015) The differential response of atrial and ventricular cells to late sodium channel current (late INa) inhibition has not been thoroughly investigated. The aim of the present study was to compare the atrioventricular differences in electrophysiological actions o... |
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Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs.
Sci. Rep. 5 , 11817, (2015) Current preclinical screening methods do not adequately detect cardiotoxicity. Using human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs), more physiologically relevant preclinical or patient-specific screening to detect potential cardiotoxic ... |
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Non-Invasive Acoustical sensing of Drug-Induced Effects on the Contractile Machinery of Human Cardiomyocyte Clusters.
PLoS ONE 10 , e0125540, (2015) There is an urgent need for improved models for cardiotoxicity testing. Here we propose acoustic sensing applied to beating human cardiomyocyte clusters for non-invasive, surrogate measuring of the QT interval and other characteristics of the contractile mach... |