廿二碳四烯酸
廿二碳四烯酸结构式
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常用名 | 廿二碳四烯酸 | 英文名 | Adrenic Acid |
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| CAS号 | 28874-58-0 | 分子量 | 332.520 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 439.5±24.0 °C at 760 mmHg | |
| 分子式 | C22H36O2 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 336.2±18.0 °C |
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Niacin sensitivity and the arachidonic acid pathway in schizophrenia.
Schizophr. Res. 122(1-3) , 248-56, (2010) Schizophrenia is associated with a blunted flush response to niacin. Since niacin-induced skin flushing is mediated by vasodilators derived from arachidonic acid (AA), we tested whether the blunted flush response to niacin is a marker of AA deficiency.Eight c... |
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Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors.
Hypertension 55(2) , 547-54, (2010) Adrenic acid (docosatetraenoic acid), an abundant fatty acid in the adrenal gland, is identical to arachidonic acid except for 2 additional carbons on the carboxyl end. Adrenic acid is metabolized by cyclooxygenases, cytochrome P450s, and lipoxygenases; howev... |
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Reevaluation of the pathway for the metabolism of 7,10,13, 16-docosatetraenoic acid to 4,7,10,13,16-docosapentaenoic acid in rat liver.
Arch. Biochem. Biophys. 317(1) , 179-84, (1995) When rat liver microsomes were incubated with [1-14C]22:4(n-6) under standard conditions for measuring acyl-CoA desaturases, it was not possible to detect the synthesis of any 22:5(n-6). When malonyl-CoA and NADPH were included in the incubation, 22:4(n-6) wa... |
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Metabolism of adrenic acid to vasodilatory 1alpha,1beta-dihomo-epoxyeicosatrienoic acids by bovine coronary arteries.
Am. J. Physiol. Heart Circ. Physiol. 292(5) , H2265-74, (2007) Adrenic acid (docosatetraenoic acid), an abundant fatty acid in the vasculature, is produced by a two-carbon chain elongation of arachidonic acid. Despite its abundance and similarity to arachidonic acid, little is known about its role in the regulation of va... |
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Arachidonic acid formed by peroxisomal beta-oxidation of 7,10,13,16-docosatetraenoic acid is esterified into 1-acyl-sn-glycero-3-phosphocholine by microsomes.
J. Biol. Chem. 269(28) , 18390-4, (1994) Peroxisomal beta-oxidation of linoleic acid and arachidonic acid was depressed when 1-palmitoyl-sn-glycero-3-phosphocholine and microsomes were included in incubations. This reduction was due to the esterification of the substrate into the acceptor by microso... |
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Unique metabolites of eicosapentaenoic acid interfere with corpus luteum function in the ewe.
Prostaglandins 44(6) , 519-30, (1992) Experiments were conducted to determine the in vivo and in vitro effects of metabolites of eicosapentaenoic acid on ovine luteal function. Injection of 750 micrograms methyl eicosapentaenoic acid (EPA) or methyl 12(R),13(S)-dihydroxyeicosapentaenoic acid (12,... |
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Significant utilization of dietary arachidonic acid is for brain adrenic acid in baboon neonates.
J. Lipid Res. 43(5) , 762-7, (2002) Dietary arachidonic acid (20:4n-6) utilization in-vivo for carbon recycling into de-novo lipogenesis and conversion to n-6 long chain polyunsaturates was investigated in baboon neonates using [U-(13)C]20:4n-6. Neonates consuming a formula typical of human mil... |
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Effect of essential fatty acid deficiency on membrane fatty acid content and growth hormone stimulation of rat pituitaries during postnatal development.
J. Lipid Res. 36(6) , 1401-6, (1995) Fatty acid composition of anterior pituitary cell membranes of rats deprived of essential fatty acids (EFA) and of rats receiving a standard diet was determined during postnatal development and in adults. Pregnant rats were fed an EFA-deficient diet and the o... |
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Priming effect of adrenic acid (22:4(n-6)) on tissue factor activity expressed by thrombin-stimulated endothelial cells.
Atherosclerosis 95(1) , 51-8, (1992) Tissue factor (TF) which initiates clotting process can be expressed by stimulated endothelial cells (EC). TF is an apolipoprotein requiring an association with phospholipids (PL) in order to become active. Also PL constitute an important storage pool of poly... |
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Effect of an essential fatty acid deficiency on the phospholipid composition in anterior pituitary membranes.
Biochem. Biophys. Res. Commun. 183(3) , 1047-55, (1992) The effects of an essential fatty acid deficient diet were investigated on the phospholipid fatty acids of several membrane fractions of the rat anterior pituitary, the secretion of which is known to be partly dependent on the membrane phospholipidic constitu... |