Adrenic Acid
Adrenic Acid structure
|
Common Name | Adrenic Acid | ||
|---|---|---|---|---|
| CAS Number | 28874-58-0 | Molecular Weight | 332.520 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 439.5±24.0 °C at 760 mmHg | |
| Molecular Formula | C22H36O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 336.2±18.0 °C | |
Use of Adrenic AcidAdrenic Acid is an inflammation enhancer in non-alcoholic fatty liver disease. |
| Name | all-cis-docosa-7,10,13,16-tetraenoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Adrenic Acid is an inflammation enhancer in non-alcoholic fatty liver disease. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Adrenic acid is produced via the elongation of arachidonic acid by ELOVL2 and 5. Interestingly, the hepatic level of free Adrenic Acid (22:4n6) is markedly higher in the CDAHFD-fed db/db mice than in the SD-fed db/db mice. In plasma, the difference in the adrenic acid level reaches statistical significance (p<0.001). It is also found that the concentrations of phospholipid species containing Adrenic Acid, such as PC or PE (40:4) (containing side chain 18:0/22:4), and LPC 22:4 (sn-1/sn-2), are also significantly increased. (sn-1/sn-2). The hepatic and plasma levels of Adrenic Acid, which is an omega 6 polyunsaturated fatty acid (PUFA), exhibit greater differences between the CDAHFD-fed db/db mice and the SD-fed db/db mice (8.6-fold higher vs. 1.6-fold higher in liver tissue, 5.3-fold higher vs. 2.2-fold higher in plasma) than those of well-known proinflammatory PUFA, such as Arachidonic Acid[1]. |
| References |
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 439.5±24.0 °C at 760 mmHg |
| Molecular Formula | C22H36O2 |
| Molecular Weight | 332.520 |
| Flash Point | 336.2±18.0 °C |
| Exact Mass | 332.271515 |
| PSA | 37.30000 |
| LogP | 7.95 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.498 |
| Storage condition | −20°C |
| Personal Protective Equipment | Eyeshields;Gloves |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
|
Niacin sensitivity and the arachidonic acid pathway in schizophrenia.
Schizophr. Res. 122(1-3) , 248-56, (2010) Schizophrenia is associated with a blunted flush response to niacin. Since niacin-induced skin flushing is mediated by vasodilators derived from arachidonic acid (AA), we tested whether the blunted fl... |
|
|
Adrenic acid metabolites as endogenous endothelium-derived and zona glomerulosa-derived hyperpolarizing factors.
Hypertension 55(2) , 547-54, (2010) Adrenic acid (docosatetraenoic acid), an abundant fatty acid in the adrenal gland, is identical to arachidonic acid except for 2 additional carbons on the carboxyl end. Adrenic acid is metabolized by ... |
|
|
Reevaluation of the pathway for the metabolism of 7,10,13, 16-docosatetraenoic acid to 4,7,10,13,16-docosapentaenoic acid in rat liver.
Arch. Biochem. Biophys. 317(1) , 179-84, (1995) When rat liver microsomes were incubated with [1-14C]22:4(n-6) under standard conditions for measuring acyl-CoA desaturases, it was not possible to detect the synthesis of any 22:5(n-6). When malonyl-... |
| adrenic acid |
| all-cis-7,10,13,16-Docosatetraenoic acid |
| 7Z,10Z,13Z,16Z-docosatetraenoic acid |
| Docosatetraenoic acid |
| CIS-7,10,13,16,19-DOCOSA-TETRAENOIC ACID |
| all-cis-docosa-7,10,13,16-tetraenoic acid |
| (7Z,10Z,13Z,16Z)-7,10,13,16-Docosatetraenoic acid |
| cis-7,10,13,16-DocosatetraenoicAcid |
| DOCOSA-7Z,10Z,13Z,16Z-PENTAENOIC ACID |
| 7,10,13,16-Docosatetraenoic acid, (7Z,10Z,13Z,16Z)- |
| (All-Z)-7,10,13,16-docosatetraenoic acid |
| CIS-7,10,13,16-DOCOSA-TETRAENOIC ACID |
| DOCOSA-7Z,10Z,13Z,16Z-TETRAENOIC ACID |