9S-羟基-10E,12Z-十八碳二烯酸
9S-羟基-10E,12Z-十八碳二烯酸结构式
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常用名 | 9S-羟基-10E,12Z-十八碳二烯酸 | 英文名 | 9(S)-HODE |
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| CAS号 | 73543-67-6 | 分子量 | 296.44500 | |
| 密度 | 0.97g/cm3 | 沸点 | 416.1ºC at 760 mmHg | |
| 分子式 | C18H32O3 | 熔点 | -144 °C | |
| MSDS | 美版 | 闪点 | 219.6ºC | |
| 符号 |
GHS02, GHS07 |
信号词 | Danger |
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Lipidomics reveals a remarkable diversity of lipids in human plasma.
J. Lipid Res. 51(11) , 3299-305, (2010) The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test and physicians r... |
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Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis.
J. Leukoc. Biol. 95(4) , 575-85, (2014) Chemokines are a diverse group of molecules with important implications for the development of solid tissues and normal function of the immune system. However, change of the conditions for such a complex system can have important and dangerous consequences le... |
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Relation of blood cadmium, lead, and mercury levels to biomarkers of lipid peroxidation in premenopausal women.
Am. J. Epidemiol. 175(7) , 645-52, (2012) Exposures to cadmium, lead, and mercury are associated with adverse health effects, including cardiovascular disease, which may be promoted by lipid peroxidation. The authors examined cadmium, lead, and mercury in relation to plasma levels of F(2)-8α isoprost... |
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Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans.
Prostaglandins Leukot. Essent. Fatty Acids 87(4-5) , 135-41, (2012) Linoleic acid (LA) is the most abundant polyunsaturated fatty acid in human diets, a major component of human tissues, and the direct precursor to the bioactive oxidized LA metabolites (OXLAMs), 9- and 13 hydroxy-octadecadienoic acid (9- and 13-HODE) and 9- a... |
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The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain.
Mol. Pain 8 , 73, (2012) Oxidized linoleic acid metabolites (OLAMs) are a class of endogenous agonists to the transient receptor potential V1 (TRPV1) receptor. Although TRPV1 mediates inflammatory heat hyperalgesia, it is not known if the OLAMs contribute to the peripheral activation... |
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Identification and profiling of targeted oxidized linoleic acid metabolites in rat plasma by quadrupole time-of-flight mass spectrometry.
Biomed. Chromatogr. 27(4) , 422-32, (2013) Linoleic acid (LA) and LA-esters are the precursors of LA hydroperoxides, which are readily converted to 9- and 13-hydroxy-octadecadienoic acid (HODE) and 9- and 13-oxo-octadecadienoic acid (oxo ODE) metabolites in vivo. These four oxidized LA metabolites (... |
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Metabolomics approach to assessing plasma 13- and 9-hydroxy-octadecadienoic acid and linoleic acid metabolite responses to 75-km cycling.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(1) , R68-74, (2014) Bioactive oxidized linoleic acid metabolites (OXLAMs) include 13- and 9-hydroxy-octadecadienoic acid (13-HODE + 9-HODE) and have been linked to oxidative stress, inflammation, and numerous pathological and physiological states. The purpose of this study was t... |
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L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice.
Drug Metab. Lett. 4(3) , 139-48, (2010) To determine in vivo if L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL. Injecting L-4F into apoE null mice resulted in a significant reduction in plasma levels of 15-HETE, 5-HETE, 13-HODE and 9-HODE. I... |
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Ex vivo oxidation in tissue and plasma assays of hydroxyoctadecadienoates: Z,E/E,E stereoisomer ratios.
Chem. Res. Toxicol. 23(5) , 986-95, (2010) The primary products from peroxidation of linoleate in biological tissues and fluids are the hydroperoxy octadecadienoates, and the products normally assayed, after reduction of the hydroperoxides, are the corresponding hydroxy octadecadienoates (HODEs). The ... |
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Dimorphecolic acid is synthesized by the coordinate activities of two divergent Delta12-oleic acid desaturases.
J. Biol. Chem. 279(13) , 12495-502, (2004) Dimorphecolic acid (9-OH-18:2Delta(10)(trans)(,12)(trans)) is the major fatty acid of seeds of Dimorphotheca species. This fatty acid contains structural features that are not typically found in plant fatty acids, including a C-9 hydroxyl group, Delta(10),Del... |