氟前列醇
氟前列醇结构式
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常用名 | 氟前列醇 | 英文名 | fluprostenol |
|---|---|---|---|---|
| CAS号 | 40666-16-8 | 分子量 | 458.46800 | |
| 密度 | 1.335g/cm3 | 沸点 | 608ºC at 760 mmHg | |
| 分子式 | C23H29F3O6 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 321.5ºC | |
| 符号 |
GHS02, GHS07 |
信号词 | Danger |
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Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes.
PLoS ONE 7(9) , e45273, (2012) Although prostanoids are known to be involved in regulation of the spontaneous beating rate of cultured neonatal rat cardiomyocytes, the various subtypes of prostanoid receptors have not been investigated in detail. In our experiments, prostaglandin (PG)F(2α)... |
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Regulation of Nur77 gene expression by prostanoids in cementoblastic cells.
Arch. Oral Biol. 54(5) , 412-9, (2009) The inflammatory cytokine interleukin-1 (IL-1) decreases mineralisation by immortalized mouse-derived cementoblastic cells (OC-CM cells), whilst various prostanoids, including fluprostenol (flup) increase it. Subtraction hybridisation conducted on flup minus ... |
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Cyclooxygenase-2-derived endogenous prostacyclin enhances mouse embryo hatching.
Hum. Reprod. 19(12) , 2900-6, (2004) The role of prostaglandins (PGs) in embryo hatching remains controversial. In addition, there is no direct evidence that mouse embryos synthesize PGs.The effects of endogenous PG on mouse embryo hatching were evaluated by blocking endogenous PG synthesis with... |
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Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: Synthesis and biological activity
Bioorg. Med. Chem. 17 , 576-84, (2009) Novel 13-oxa prostaglandin analogs were designed, synthesized and evaluated for their antiglaucoma activities. AL-16082 was the most potent prostaglandin FP agonist in vitro (EC 50 = 1.9 nM). Its pro-drug AL-16049 significantly lowered intraocular pressure in... |
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Prostanoid- and interleukin-1-induced primary genes in cementoblastic cells.
J. Periodontol. 77(8) , 1362-70, (2006) Cementum is a key component of a functional periodontal organ. However, regenerating lost cementum is difficult and often incomplete. Identifying molecular mediators of cementoblast differentiation and function should lead to better targeted treatment for per... |
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Excitatory action of prostanoids on the ferret isolated vagus nerve preparation.
Eur. J. Pharmacol. 491(1) , 37-41, (2004) We have investigated the actions of various prostanoid receptor agonists on an isolated preparation of the ferret cervical vagus using a grease-gap extracellular recording technique. The potency ranking for depolarization was BW245C (5-(6-carboxyhexyl)-1-(3-c... |
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PGF2alpha-associated vascular smooth muscle hypertrophy is ROS dependent and involves the activation of mTOR, p70S6k, and PTEN.
Prostaglandins Other Lipid Mediat. 85(1-2) , 49-57, (2008) Prostaglandin F2alpha (PGF2alpha) increases reactive oxygen species (ROS) and induces vascular smooth muscle cell (VSMC) hypertrophy by largely unknown mechanism(s). To investigate the signaling events governing PGF2alpha-induced VSMC hypertrophy we examined ... |
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Effect of femto to nano molar concentrations of prostaglandin analogues on pregnant rat uterine contractility.
Eur. J. Pharmacol. 581(1-2) , 185-90, (2008) Prostaglandins are bioactive lipids and important mediators of uterine relaxation as well as contraction during pregnancy and labour. E series prostaglandins may directly contract or relax myometrium in a dose-dependent manner, with the relaxatory effects med... |
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Implication of prostaglandin receptors in the accumulation of osteoprotegerin in human osteoblast cultures.
J. Rheumatol. 33(6) , 1167-75, (2006) Prostaglandins are important mediators in bone metabolism and in pathologies such as rheumatoid arthritis and osteoarthritis. We investigated the roles of cyclooxygenases (COX) and prostaglandin receptors in the accumulation of osteoprotegerin (OPG) in the su... |
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Investigation of the pronounced synergism between prostaglandin E2 and other constrictor agents on rat femoral artery.
Prostaglandins Leukot. Essent. Fatty Acids 74 , 401-15, (2006) This study investigates the pronounced synergism between the weak contractile action of prostaglandin E(2) (PGE(2)) and strong actions of phenylephrine, U-46619 and K(+) on rat isolated femoral artery. The potency ranking for synergism was SC-46275 (prostanoi... |