人内皮素3
人内皮素3结构式
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常用名 | 人内皮素3 | 英文名 | Endothelin-3 (human, mouse, rabbit, rat) acetate salt |
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| CAS号 | 117399-93-6 | 分子量 | 2643.04000 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C121H168N26O33S4 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Involvement of endothelins in deoxycorticosterone acetate-salt hypertension through the modulation of noradrenergic transmission in the rat posterior hypothalamus.
Exp. Physiol. 100 , 617-27, (2015) What is the central question of this study? Does ex vivo administration of endothelin-1 and endothelin-3 regulate noradrenergic transmission in the posterior hypothalamus of deoxycorticosterone acetate-salt hypertensive rats compared with normotensive rats? W... |
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Direct conversion of mouse and human fibroblasts to functional melanocytes by defined factors.
Nat. Commun. 5 , 5807, (2014) Direct reprogramming provides a fundamentally new approach for the generation of patient-specific cells. Here, by screening a pool of candidate transcription factors, we identify that a combination of the three factors, MITF, SOX10 and PAX3, directly converts... |
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Analysis of immunostaining and western blotting of endothelin 1 and its receptors in mitral stenosis.
Rev. Bras. Cir. Cardiovasc. 30 , 211-8, (2015) Rheumatic Fever represents a serious public health problem in developing countries, with thousands of new cases each year. It is an autoimmune disease, which occurs in response to infection by streptococcus A.The aim of this study was to evaluate the immunola... |
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Role of the endothelin axis in astrocyte- and endothelial cell-mediated chemoprotection of cancer cells.
Neuro. Oncol. 16(12) , 1585-98, (2014) Recent evidence suggests that astrocytes protect cancer cells from chemotherapy by stimulating upregulation of anti-apoptotic genes in those cells. We investigated the possibility that activation of the endothelin axis orchestrates survival gene expression an... |
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The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
Proc. Natl. Acad. Sci. U. S. A. 86 , 2863-2867, (1989) Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the endothelin sequence. Genomic Southern blot analysis with the sam... |
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Silencing endothelin-3 expression attenuates the malignant behaviors of human melanoma cells by regulating SPARC levels.
J. Huazhong Univ. Sci. Technolog. Med. Sci. 33(4) , 581-6, (2013) Endothelin-3 (ET-3) is aberrantly expressed in both metastatic melanoma tissues and cultured melanoma cells. Our previous work showed that ET-3 could promote survival of metastatic melanoma cells via its altered expression. In this study, we investigated the ... |
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Endothelin-3 stimulates survival of goblet cells in organotypic cultures of fetal human colonic epithelium.
Am. J. Physiol. Gastrointest. Liver Physiol. 295(6) , G1182-9, (2008) Cells within the normal human colonic epithelium undergo a dynamic cycle of growth, differentiation, and death. The organotypic culture system of human fetal colonic epithelial cells seeded on top of collagen gels with embedded colonic fibroblasts allowed pro... |
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Ednrb2 orients cell migration towards the dorsolateral neural crest pathway and promotes melanocyte differentiation.
Pigment Cell Res. 18(3) , 181-7, (2005) Endothelin receptors B (Ednrb) are involved in the development of the enteric and melanocytic lineages, which originate from neural crest cells (NCCs). In mice, trunk NCCs and their derivatives express only one Ednrb. In quail, trunk NCCs express two Ednrb: E... |
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Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development.
Proc. Natl. Acad. Sci. U. S. A. 97(18) , 10050-5, (2000) Wnt1 signaling has been implicated as one factor involved in neural crest-derived melanocyte (NC-M) development. Mice deficient for both Wnt1 and Wnt3a have a marked deficiency in trunk neural crest derivatives including NC-Ms. We have used cell lineage-direc... |
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Endothelin 3 induces the reversion of melanocytes to glia through a neural crest-derived glial-melanocytic progenitor.
Proc. Natl. Acad. Sci. U. S. A. 97(14) , 7882-7, (2000) Functional signaling of endothelin 3 (ET3) and its receptor B (ETRB) has been shown to be required for the development of neural crest (NC)-derived pigment cells in mouse, but the precise role of ET3 is not completely understood. Using the avian embryo as a m... |