琥布宗
琥布宗结构式
|
常用名 | 琥布宗 | 英文名 | Suxibuzone |
|---|---|---|---|---|
| CAS号 | 27470-51-5 | 分子量 | 438.47300 | |
| 密度 | 1.265g/cm3 | 沸点 | 590.1ºC at 760 mmHg | |
| 分子式 | C24H26N2O6 | 熔点 | 126-127° | |
| MSDS | 美版 | 闪点 | 310.7ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
|
[The biological fate of 4-butyl-4-(beta-carboxypropionyloxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione(suxibuzone), antiinflammatory drug. I. Plasma levels and urinary excretion after oral administration of suxibuzone (author's transl)].
Yakugaku Zasshi 99(12) , 1186-200, (1979)
|
|
|
[The biological fate of 4-butyl-4-(beta-carboxypropionyloxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione (suxibuzone), antiinflammatory drug. II. The biological fate of suxibuzone (SB) after daily oral administration (author's transl)].
Yakugaku Zasshi 100(3) , 272-9, (1980)
|
|
|
Pro-drugs of non-steroidal anti-inflammatory agents.
Eur. J. Rheumatol. Inflamm. 6(2) , 141-2, (1983)
|
|
|
Antemortem diagnosis of a distal axonopathy causing severe stringhalt in a horse.
J. Vet. Intern. Med. 24(1) , 220-3, (2010)
|
|
|
Disposition of human drug preparations in the horse. I. Rectally administered indomethacin.
J. Vet. Pharmacol. Ther. 14(2) , 145-9, (1991) A high-performance liquid chromatographic method to measure urinary indomethacin levels is described. In 0.5 ml urine, 1 micrograms/ml of indomethacin could be detected. Alkaline hydrolysis of urine resulted in the decomposition of indomethacin. When two supp... |
|
|
Effects of top-dress formulations of suxibuzone and phenylbutazone on development of gastric ulcers in horses.
Vet. Ther. 10(3) , 113-20, (2009) Eighteen mature, healthy horses were divided into three groups (six per group) receiving either no treatment, 15 consecutive days of phenylbutazone (PBZ), or 15 consecutive days of suxibuzone (SBZ) at recommended label doses. Horses underwent endoscopy before... |
|
|
The disposition of suxibuzone in the horse.
J. Vet. Pharmacol. Ther. 16(3) , 283-90, (1993) A high performance liquid chromatographic method is described to determine the anti-inflammatory drug suxibuzone (SXB) and its major metabolites phenylbutazone (PBZ) and oxyphenbutazone (OPBZ) in equine plasma and urine. When suxibuzone (6 mg/kg) was administ... |
|
|
Lower gastric ulcerogenic effect of suxibuzone compared to phenylbutazone when administered orally to horses.
Res. Vet. Sci. 76(2) , 145-9, (2004) The objective was to compare the gastrointestinal and general toxicity of suxibuzone (SBZ) to that of phenylbutazone (PBZ) when administered orally in horses. Fifteen healthy horses were allocated to three treatment groups. One group received a high dose of P... |
|
|
Multicentre, controlled, randomised and blinded field study comparing efficacy of suxibuzone and phenylbutazone in lame horses.
Equine Vet. J. 41(7) , 700-5, (2009) In horses, it has been demonstrated that suxibuzone (SBZ) has a lower gastric ulcerogenic effect than phenylbutazone (PBZ). However, no field trials have been reported comparing the efficacy of the drugs in alleviating lameness.To compare the therapeutic effe... |
|
|
Solid-phase extraction for the high-performance liquid chromatographic determination of indomethacin, suxibuzone, phenylbutazone and oxyphenbutazone in plasma, avoiding degradation of compounds.
J. Chromatogr. A. 581(1) , 101-7, (1992) A solid-phase extraction method was validated for the simultaneous high-performance liquid chromatographic determination of indomethacin, suxibuzone, phenylbutazone, oxyphenbutazone and their degradation products. Indomethacin was added as internal standard t... |