阿脲,一水合物
阿脲,一水合物结构式
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常用名 | 阿脲,一水合物 | 英文名 | Pyrimidine-2,4,5,6(1H,3H)-tetraone hydrate |
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| CAS号 | 2244-11-3 | 分子量 | 160.085 | |
| 密度 | 1.681g/cm3 | 沸点 | 374.1ºC at 760 mmHg | |
| 分子式 | C4H4N2O5 | 熔点 | 255 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 180ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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Investigation of antidiabetic action of Antidesma bunius extract in type 1 diabetes.
Arch. Physiol. Biochem. 121 , 116-22, (2015) Antidesma bunius L (Phyllanthaceae) is commonly known to local people in North-east Thailand as a medicinal plant.To investigate hypoglycaemic activities of methanolic extract of A. bunius in type 1 diabetes.A daily dose of A. bunius extract (250 mg/kg body w... |
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Blighia sapida leaves halt elevated blood glucose, dyslipidemia and oxidative stress in alloxan-induced diabetic rats.
J. Ethnopharmacol. 157 , 309-19, (2014) Blighia sapida leaves are used in the management of diabetes in Nigeria. Thus the antidiabetic activity of methanolic Blighia sapida leaf extract and its capability to halt oxidative stress and dyslipidemia in alloxan-induced diabetic rats were investigated.I... |
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Sepsis-induced lung inflammation is modulated by insulin.
BMC Pulm. Med. 14 , 177, (2014) We have previously shown that diabetic rats are more susceptible to sepsis, but that the Acute lung injury (ALI) secondary to sepsis is less intense than in non-diabetics. In the present study, we further investigated the ALI-secondary to sepsis in diabetic r... |
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pH-sensitive chitosan/alginate core-shell nanoparticles for efficient and safe oral insulin delivery.
Int. J. Biol. Macromol. 72 , 640-8, (2014) Chitosan-alginate (CS/ALG) nanoparticles were prepared by formation of an ionotropic pre-gelation of an alginate (ALG) core entrapping insulin, followed by chitosan (CS) polyelectrolyte complexation, for successful oral insulin administration. Mild preparatio... |
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The effect of hyperglycemia on the pharmacokinetics of valproic acid studied by high-performance liquid chromatography with electrochemical detection.
J. Pharm. Biomed. Anal. 97 , 47-53, (2014) The effects of hyperglycemia on the pharmacokinetics of valproic acid (VPA) were examined by time-concentration profiles of plasma VPA accompanied with blood glucose (BG) changing. In addition, time-concentration profiles of plasma free fatty acids (FFAs) wer... |
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Effect of kolaviron, a biflavonoid complex from Garcinia kola seeds, on the antioxidant, hormonal and spermatogenic indices of diabetic male rats.
Andrologia 46(8) , 878-86, (2014) The antihyperglycaemic effect of kolaviron (KV), a biflavonoid from Garcinia kola has been established in previous studies. In this study, we investigated the effect of KV (200 mg kg(-1) ) on the antioxidant, hormonal and spermatogenic indices of alloxan-diab... |
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Morus nigra leaf extract improves glycemic response and redox profile in the liver of diabetic rats.
Food Funct. 6 , 3490-9, (2015) Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia and alterations in the carbohydrate, lipid, and protein metabolism. DM is associated with increased oxidative stress and pancreatic beta cell damage, which impair the produc... |