苯磺酰胺
苯磺酰胺结构式
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常用名 | 苯磺酰胺 | 英文名 | Benzenesulfonamide |
|---|---|---|---|---|
| CAS号 | 98-10-2 | 分子量 | 157.19 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 299.1±23.0 °C at 760 mmHg | |
| 分子式 | C6H7NO2S | 熔点 | 149-152 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 134.7±22.6 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Efficient tandem solid-phase extraction and liquid chromatography-triple quadrupole mass spectrometry method to determine polar benzotriazole, benzothiazole and benzenesulfonamide contaminants in environmental water samples.
J. Chromatogr. A. 1309 , 22-32, (2013) An analytical method has been developed that allows the simultaneous determination of five benzotriazole (BTRs), four benzothiazole (BTs) and five benzenesulfonamide (BSAs) derivates. The method is based on tandem solid-phase extraction (SPE) with Oasis HLB f... |
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Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus.
J. Clin. Invest. 124(6) , 2683-95, (2014) In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein-coupled receptor endothelin A recepto... |
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Amorphous drug dispersions with mono- and diacyl lecithin: On molecular categorization of their feasibility and UV dissolution imaging.
Int. J. Pharm. 491 , 218-30, (2015) There is a growing interest in drug-phospholipid complexes and similar formulations that are mostly solid dispersions with high drug load. This study aims to explore the feasibility of such phospholipid-based solid dispersions as well as to characterize them.... |
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Beta adrenergic modulation of spontaneous microcontractions and electrical field-stimulated contractions in isolated strips of rat urinary bladder from normal animals and animals with partial bladder outflow obstruction.
Naunyn Schmiedebergs Arch. Pharmacol. 388 , 719-26, (2015) Spontaneous microcontractions and electrical field stimulation (EFS)-evoked contractions in isolated rat bladder strips from normal and from 6 weeks partial bladder outflow obstruction (pBOO) animals were studied to identify the potential site of action for t... |
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Benzenesulfonamides: a unique class of chemokine receptor type 4 inhibitors.
ChemMedChem 8(4) , 622-32, (2013) The interaction of CXCR4 with CXCL12 (SDF-1) plays a critical role in cancer metastasis by facilitating the homing of tumor cells to metastatic sites. Based on our previously published work on CXCR4 antagonists, we have synthesized a series of aryl sulfonamid... |
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Synthesis and evaluation of anticancer activity of some novel 6-aryl-2-(p-sulfamylphenyl)-pyridazin-3(2H)-ones.
Eur. J. Med. Chem. 49C , 304-9, (2012) A series of novel pyridazinone derivatives bearing benzenesulfonamide moiety (2a-h) has been synthesized by the condensation of appropriate aroylacrylic acid and 4-hydrazinobenzenesulfonamide hydrochloride in ethanol. Five derivatives (2a, 2b, 2d, 2g and 2h) ... |
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Simultaneous determination of benzothiazoles, benzotriazoles and benzosulfonamides by solid phase microextraction-gas chromatography-triple quadrupole mass spectrometry in environmental aqueous matrices and human urine
J. Chromatogr. A. 1338 , 164-73, (2014) • Benzothiazoles, benzotriazoles and benzosulfonamides determination in aqueous matrices. • New environmental-friendly and high-throughput protocol developed by SPME-GC-QqQMS. • Sample preparation strategy completely avoids the use of organic solvents. • MRM ... |
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Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.
Bioorg. Med. Chem. Lett. 22 , 1352-7, (2012) The Naturally occurring novel cyclohexanonyl bromophenol 2(R)-2-(2,3,6-tribromo-4,5-dihydroxybenzyl)cyclohexanone (4) was synthesized as a racemic compound. Cyclohexylphenyl methane derivatives (10-17) with Br, OMe, CO, and OH were also obtained. Inhibition o... |
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Synthesis of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide as anticancer and anti-inflammatory agents.
Bioorg. Med. Chem. Lett. 21(14) , 4301-5, (2011) Thirteen new 2-pyrazoline derivatives bearing benzenesulfonamide moiety (2a-m) were synthesized by condensing appropriate chalcones with 4-hydrazinonbenzenesulfonamide hydrochloride and tested for anticancer and anti-inflammatory actions. According to the pro... |
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Carbonic anhydrase inhibitors: benzenesulfonamides incorporating cyanoacrylamide moieties are low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms IX and XII.
Bioorg. Med. Chem. 21(6) , 1396-403, (2013) A series of benzenesulfonamides incorporating cyanoacrylamide moieties (tyrphostine analogues) have been obtained by reaction of sulfanilamide with ethylcyanoacetate followed by condensation with aromatic/heterocyclic aldehydes, isothiocyanates or diazonium s... |