丁炔二酸
丁炔二酸结构式
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常用名 | 丁炔二酸 | 英文名 | 2-Butynedioic acid |
|---|---|---|---|---|
| CAS号 | 142-45-0 | 分子量 | 114.056 | |
| 密度 | 1.7±0.1 g/cm3 | 沸点 | 362.4±25.0 °C at 760 mmHg | |
| 分子式 | C4H2O4 | 熔点 | 180-187 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 187.2±19.7 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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An efficient and facile synthesis of 3-amino-5-chromenyl-butenolides from 3-formyl chromone, dialkyl acetylenedicarboxylate, and primary amines.
Mol. Divers. 17(1) , 55-61, (2013) A three-component reaction of 3-formyl chromones, dialkyl acetylenedicarboxylate, and isocyanides in the presence of POCl(3) was used as a highly efficient and practical approach for the synthesis of 3-amino-5-chromenyl-butenolides. High yields and high bond ... |
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Efficient synthesis and in vitro antitubercular activity of 1,2,3-triazoles as inhibitors of Mycobacterium tuberculosis.
Bioorg. Med. Chem. Lett. 21 , 7273-6, (2011) Efficient and rapid synthesis of 1,2,3-triazole derivatives has been achieved via Huisgen's 1,3-dipolar cycloaddition between alkyl/arylazides and diethyl/dimethyl acetylenedicarboxylate in excellent yields under solvent-free conditions. The environmentally f... |
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Synthesis of symmetrical and unsymmetrical diarylalkynes from propiolic acid using palladium-catalyzed decarboxylative coupling.
J. Org. Chem. 75(18) , 6244-51, (2010) Symmetrical diarylalkynes were obtained from propiolic acid (or 2-butynedioic acid) and aryl halides in good yields. The optimized reaction conditions were 2.0 equiv of aryl halide, 1.0 equiv of propiolic acid, 5.0 mol % Pd(PPh(3))(2)Cl(2), 10.0 mol % 1,4-bis... |
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Three-component synthesis of dialkyl 2-(alkylimino-methylene)3- (2,2,5-trimethyl-4,6-dioxo-1,3-dioxan-5-yl)-succinates.
Mol. Divers. 10(2) , 247-50, (2006) The adduct produced in the reaction between alkyl isocyanides and dialkyl acetylenedicarboxylates was trapped by 2,2,5-trimethyl-1,3-dioxane-4,6-dione (methyl Meldrum's acid), to afford highly functionalized ketenimines in good yields. |
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Three-component reactions of isocyanides, dialkyl acetylenedicarboxylates, and trans-cinnamoyl chlorides for the synthesis of highly functionalized 2-vinyl furans.
Mol. Divers. 16(1) , 145-50, (2012) In this study, we present a convenient and efficient method for the synthesis of novel, highly substituted 2-vinyl furans using a three-component reaction. The zwitterions generated from the reaction of isocyanides and dialkyl acetylenedicarboxylates are reac... |
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Diversity oriented syntheses of conventional heterocycles by smart multi component reactions (MCRs) of the last decade.
Molecules 17(1) , 1074-102, (2012) A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS). These will provide a hi... |
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Three-component synthesis of functionalized 5-oxo-4,5-dihydroindeno[1,2-b]pyrans.
Mol. Divers. 10(2) , 265-70, (2006) Protonation of the reactive intermediates produced in the reaction between alkyl(aryl) isocyanides and dialkyl acetylenedicarboxylates by indan-1,3-dione leads to vinylnitrilium cations, which undergo carbon centered Michael type addition with the conjugate b... |
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In situ proton NMR analysis of alpha-alkynoate biotransformations. From 'invisible' substrates to detectable metabolites.
Eur. J. Biochem. 270(7) , 1393-8, (2003) Only 2% of the known natural products with acetylenic bonds are alpha-alkynoates. Their polarized, conjugated triple bond is an optimal target for an enzymic hydration. Therefore they are good substrates for the enzymes involved in metabolism of acetylenic co... |
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Urea-acetylene dicarboxylic acid reaction: a likely pathway for prebiotic uracil formation.
Orig. Life 10(4) , 343-7, (1980) A number of routes have been suggested for the prebiotic synthesis of uracil involving the reaction of urea with malic acid, propiolic acid, cyanoacetylene and others. Cyanoacetylene has been detected in the interstellar medium as well as simulated prebiotic ... |
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Identification of an intermediate in the de novo formation of nicotinamide adenine dinucleotide in Escherichia coli.
Biochem. Biophys. Res. Commun. 95(4) , 1517-21, (1980)
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