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VU 0240551

VU 0240551结构式
VU 0240551结构式
品牌特惠专场
常用名 VU 0240551 英文名 VU 0240551
CAS号 893990-34-6 分子量 342.43900
密度 N/A 沸点 N/A
分子式 C16H14N4OS2 熔点 N/A
MSDS 中文版 美版 闪点 N/A

Chloride dysregulation and inhibitory receptor blockade yield equivalent disinhibition of spinal neurons yet are differentially reversed by carbonic anhydrase blockade.

Pain 156 , 2431-7, (2015)

Synaptic inhibition plays a key role in processing somatosensory information. Blocking inhibition at the spinal level is sufficient to produce mechanical allodynia, and many neuropathic pain conditions are associated with reduced inhibition. Disinhibition of ...

Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis.

PLoS Comput. Biol. 7 , e1002149, (2011)

Chloride homeostasis is a critical determinant of the strength and robustness of inhibition mediated by GABA(A) receptors (GABA(A)Rs). The impact of changes in steady state Cl(-) gradient is relatively straightforward to understand, but how dynamic interplay ...