VU 0240551
VU 0240551 structure
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Common Name | VU 0240551 | ||
|---|---|---|---|---|
| CAS Number | 893990-34-6 | Molecular Weight | 342.43900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H14N4OS2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Chloride dysregulation and inhibitory receptor blockade yield equivalent disinhibition of spinal neurons yet are differentially reversed by carbonic anhydrase blockade.
Pain 156 , 2431-7, (2015) Synaptic inhibition plays a key role in processing somatosensory information. Blocking inhibition at the spinal level is sufficient to produce mechanical allodynia, and many neuropathic pain conditions are associated with reduced inhibition. Disinhibition of ... |
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Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis.
PLoS Comput. Biol. 7 , e1002149, (2011) Chloride homeostasis is a critical determinant of the strength and robustness of inhibition mediated by GABA(A) receptors (GABA(A)Rs). The impact of changes in steady state Cl(-) gradient is relatively straightforward to understand, but how dynamic interplay ... |
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