BML-266
BML-266结构式
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常用名 | BML-266 | 英文名 | BML-266 |
|---|---|---|---|---|
| CAS号 | 96969-83-4 | 分子量 | 478.538 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 780.2±60.0 °C at 760 mmHg | |
| 分子式 | C30H26N2O4 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 425.7±32.9 °C | |
| 符号 |
GHS09 |
信号词 | Warning |
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An in silico approach to discovering novel inhibitors of human sirtuin type 2.
J. Med. Chem. 47 , 6292-6298, (2004) Type 2 human sirtuin (SIRT2) is a NAD(+)-dependent cytoplasmic protein that is colocalized with HDAC6 on microtubules. SIRT2 has been shown to deacetylate alpha-tubulin and to control mitotic exit in the cell cycle. To date, some small molecular inhibitors of... |
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Discovering inhibitors of human sirtuin type 2: novel structural scaffolds.
J. Med. Chem. 49 , 7239-7241, (2006) A successful virtual screening experiment of novel SIRT2 inhibitors is described. Four out of 11 experimentally tested compounds showed in vitro inhibitory activity toward SIRT2 in a micromolar level, resulting in an experimental hit ratio of 36%. Two of thes... |
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