3α,5β-四氢醛固酮
3α,5β-四氢醛固酮结构式
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常用名 | 3α,5β-四氢醛固酮 | 英文名 | Tetrahydro Aldosterone |
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| CAS号 | 13489-75-3 | 分子量 | 364.47600 | |
| 密度 | 1.29g/cm3 | 沸点 | 557.5ºC at 760mmHg | |
| 分子式 | C21H32O5 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 195.4ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Urinary tetrahydroaldosterone as a screening method for primary aldosteronism: a comparative study.
Am. J. Hypertens. 16(7) , 522-30, (2003) The major aldosterone metabolite 3 alpha,5 beta tetrahydroaldosterone reflects up to 45% of the aldosterone secretion. Its 24-h urinary excretion is likely to provide an accurate index of the daily aldosterone production and to be an indicator for primary ald... |
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Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.
J. Clin. Endocrinol. Metab. 91(12) , 5051-6, (2006) Variation in the region of chromosome 8 including the genes steroid 11beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid and glucocorticoid metabolism. However, the relative importance of polymorphisms in CYP11B1 and CY... |
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Effect of uremia on aldosterone metabolism in the isolated perfused rat liver.
Metab. Clin. Exp. 42(4) , 470-6, (1993) The effect of uremia on hepatic metabolism of aldosterone was studied in the isolated perfused liver of female Wistar rats. Uremia was induced by five-sixths partial nephrectomy 4 weeks before experiments. Isolated livers of normal and uremic rats were perfus... |
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Converting-enzyme inhibitor administration lowers urinary free 19-nor-deoxycorticosterone levels.
Hypertension 7(2) , 178-81, (1985) 19-Nor-deoxycorticosterone (19-nor-DOC) is a human mineralocorticoid. The regulation of its secretion is poorly understood, as renin angiotensin II (ANG II) stimulation has minimal effects on 19-nor-DOC. This study sought to determine if ANG II inhibition wou... |
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High-performance liquid chromatography in the radioimmunoassay of urinary tetrahydroaldosterone.
J. Chromatogr. A. 385 , 393-6, (1987)
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HPLC isolation and GC-MS characterization of a compound strongly cross reacting with tetrahydroaldosterone antiserum.
J. Steroid Biochem. 25(1) , 71-82, (1986) Urines from patients with hypertension and elevated aldosterone levels, i.e. primary aldosteronism due to adrenal adenoma or hyperplasia or carcinoma were extracted, paper chromatographed and thereafter chromatographed repeatedly with normal phase and repeate... |
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Urinary corticosteroid excretion predicts left ventricular mass and proteinuria in chronic kidney disease.
Clin. Sci. 123(5) , 285-94, (2012) Blockade of the MR (mineralocorticoid receptor) in CKD (chronic kidney disease) reduces LVMI [LV (left ventricular) mass index] and proteinuria. The MR can be activated by aldosterone, cortisol and DOC (deoxycorticosterone). The aim of the present study was t... |
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Further studies on the mechanism of the mineralocorticoid action of licorice in humans.
J. Endocrinol. Invest. 19(9) , 624-9, (1996) The pathogenesis of pseudohyperaldosteronism from licorice has been evaluated in 6 male volunteers taking daily 7 g of a commercial preparation of licorice for 7 days, corresponding to an intake of 500 mg/day of glycyrrhizic acid. Pseudohyperaldosteronism was... |
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Reversal of diuretic-induced secondary hyperaldosteronism and hypokalemia by trilostane, an inhibitor of adrenal steroidogenesis.
Metab. Clin. Exp. 38(4) , 353-6, (1989) Correction of diuretic-induced hypokalemia is usually accomplished by potassium supplementation or antagonism of aldosterone's renal action. This study sought to determine if inhibition of aldosterone biosynthesis could reverse diuretic-induced hypokalemia an... |
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High performance liquid chromatographic determination of 3 alpha, 5 beta-tetrahydroaldosterone and cortisol in human urine with fluorescence detection.
Biomed. Chromatogr. 6(5) , 217-21, (1992) A simple and sensitive method for the simultaneous determination of 3 alpha, 5 beta-tetrahydroaldosterone (THALD) and cortisol in human urine is described. The method uses high performance liquid chromatography with fluorescence detection. THALD and cortisol,... |