5a-雄甾烷-3a,17b-二醇
5a-雄甾烷-3a,17b-二醇结构式
|
常用名 | 5a-雄甾烷-3a,17b-二醇 | 英文名 | 5a-Androstane-3a,17b-diol |
|---|---|---|---|---|
| CAS号 | 1852-53-5 | 分子量 | 292.45600 | |
| 密度 | 1.09g/cm3 | 沸点 | 415ºC at 760 mmHg | |
| 分子式 | C19H32O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A |
|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
|
|
An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.
J. Med. Chem. 51 , 2047-56, (2008) A benchmark data set of steroids with known affinity for sex hormone-binding globulin (SHBG) has been widely used to validate popular molecular field-based QSAR techniques. We have expanded the data set by adding a number of nonsteroidal SHBG ligands identifi... |
|
|
Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.
J. Med. Chem. 51 , 1831-41, (2008) TGR5, a metabotropic receptor that is G-protein-coupled to the induction of adenylate cyclase, has been recognized as the molecular link connecting bile acids to the control of energy and glucose homeostasis. With the aim of disclosing novel selective modulat... |
|
|
Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.
J. Med. Chem. 52 , 7488-502, (2009) 17beta-Hydroxysteroid dehydrogenase type 7 (17beta-HSD7) catalyzes the reduction of estrone (E(1)) into estradiol (E(2)) and of dihydrotestosterone (DHT) into 5alpha-androstane-3beta,17beta-diol (3beta-diol), therefore modulating the level of mitogenic estrog... |
|
|
Chemometric and chemoinformatic analyses of anabolic and androgenic activities of testosterone and dihydrotestosterone analogues.
Bioorg. Med. Chem. 16 , 6448-59, (2008) Predictive quantitative structure-activity relationship (QSAR) models of anabolic and androgenic activities for the testosterone and dihydrotestosterone steroid analogues were obtained by means of multiple linear regression using quantum and physicochemical m... |
|
|
Improvement of neuronal bioenergetics by neurosteroids: implications for age-related neurodegenerative disorders.
Biochim. Biophys. Acta 1842(12 Pt A) , 2427-38, (2014) The brain has high energy requirements to maintain neuronal activity. Consequently impaired mitochondrial function will lead to disease. Normal aging is associated with several alterations in neurosteroid production and secretion. Decreases in neurosteroid le... |
|
|
Effect of testosterone, its 5 alpha-reduced metabolites and the corresponding propionates on testosterone metabolism. I--In the hypothalamus and in the anterior pituitary.
J. Steroid Biochem. 11(1A) , 215-9, (1979)
|
|
|
Effect of testosterone, its 5 alpha-reduced metabolites and the corresponding propionates on testosterone metabolism--II. In the ventral prostate and in the seminal vesicles.
J. Steroid Biochem. 11(1A) , 221-5, (1979)
|
|
|
The identification and simultaneous quantification of neuroactive androstane steroids and their polar conjugates in the serum of adult men, using gas chromatography-mass spectrometry.
Steroids 72(11-12) , 792-801, (2007) Certain androstane steroids (AS) modulate ionotropic receptors, as do the pregnane steroids. Whereas women produce significant amounts of neuroactive progesterone metabolites, the steroid neuromodulators in men originate mainly from the 3-oxo-4-ene C(19)-ster... |
|
|
17α-ethynyl-5α-androstane-3α, 17β-diol treatment of MNU-induced mammary cancer in rats Ahlem, C., et al.
Int. J. Breast Cancer , doi: 10.4061/2011/618757, (2011)
|