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2,4,6-三(二甲氨基)均三嗪

2,4,6-三(二甲氨基)均三嗪结构式
2,4,6-三(二甲氨基)均三嗪结构式
品牌特惠专场
常用名 2,4,6-三(二甲氨基)均三嗪 英文名 Altretamine
CAS号 645-05-6 分子量 210.279
密度 1.1±0.1 g/cm3 沸点 339.4±25.0 °C at 760 mmHg
分子式 C9H18N6 熔点 171-175 °C(lit.)
MSDS 中文版 美版 闪点 159.1±23.2 °C
符号 GHS07
GHS07
信号词 Warning

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ...

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives, and the theoretical pr...

FDA-approved drug labeling for the study of drug-induced liver injury.

Drug Discov. Today 16 , 697-703, (2011)

Drug-induced liver injury (DILI) is a leading cause of drugs failing during clinical trials and being withdrawn from the market. Comparative analysis of drugs based on their DILI potential is an effective approach to discover key DILI mechanisms and risk fact...

Liposomes incorporating sodium deoxycholate for hexamethylmelamine (HMM) oral delivery: development, characterization, and in vivo evaluation.

Drug Deliv. 17(3) , 164-70, (2010)

Liposomes incorporating sodium deoxycholate (NaDC) were prepared by the method of reverse phase evaporation and used for drug delivery by the oral route. Hexamethylmelamine (HMM), an anti-tumor agent, was chosen as a model drug and encapsulated into liposomes...

Synthesis and cytotoxic activity of trisubstituted-1,3,5-triazines.

Bioorg. Med. Chem. Lett. 17 , 3298-304, (2007)

1,3,5-Triazine derivatives were screened for phototoxicity as well as the cytotoxic activities against leukemia and adenocarcinoma derived cell lines in comparison to the normal human keratinocytes. A simple and environmentally friendly procedure has been dev...

QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.

Eur. J. Med. Chem. 45 , 1639-47, (2010)

Three different splits into the subtraining set (n = 22), the set of calibration (n = 21), and the test set (n = 12) of 55 antineoplastic agents have been examined. By the correlation balance of SMILES-based optimal descriptors quite satisfactory models for t...

[Reaction of furosemide, quimethazine and hydrochlorothiazide with thymol and sodium hypochorite].

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[High-dose chemotherapy in ovarian adenocarcinoma].

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Lessons from a time capsule: evolution, not revolution, in therapy for advanced non-small-cell lung cancer.

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Chemotherapy for ovarian cancer: beyond paclitaxel plus carboplatin.

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