利福喷丁
利福喷丁结构式
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常用名 | 利福喷丁 | 英文名 | Rifapentine |
|---|---|---|---|---|
| CAS号 | 61379-65-5 | 分子量 | 877.031 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 969.3±65.0 °C at 760 mmHg | |
| 分子式 | C47H64N4O12 | 熔点 | 179-180ºC | |
| MSDS | 中文版 美版 | 闪点 | 540.0±34.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.
Antimicrob. Agents Chemother. 58(6) , 3168-76, (2014) Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS c... |
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Novel Inhaled Combination Powder Containing Amorphous Colistin and Crystalline Rifapentine with Enhanced Antimicrobial Activities against Planktonic Cells and Biofilm of Pseudomonas aeruginosa for Respiratory Infections.
Mol. Pharm. 12 , 2594-603, (2015) Colistin has been increasingly used for the treatment of respiratory infections caused by Gram-negative bacteria. Unfortunately parenteral administration of colistin can cause severe adverse effects. This study aimed to develop an inhaled combination dry powd... |
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Bacteriological characterization of a Mycobacterium parascrofulaceum strain isolated from a Chinese pneumonia patient.
Int. J. Infect. Dis. 25 , 82-7, (2014) A Mycobacterium parascrofulaceum strain was isolated from a pneumonia patient-the first such reported case from China. The bacteriological characteristics of the strain were determined.Species identification was performed by homologue gene sequence comparison... |
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Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.
Biol. Pharm. Bull. 38 , 1425-9, (2015) The direct inhibitory potential of twenty five anti-tuberculosis drugs on eight CYP-specific reactions in human liver microsomes was investigated to predict in vivo drug-drug interactions (DDIs) from in vitro data. Rifampicin, rifabutin, and thioacetazone inh... |
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Bioluminescence for assessing drug potency against nonreplicating Mycobacterium tuberculosis.
Antimicrob. Agents Chemother. 59 , 4012-9, (2015) Targeting dormant Mycobacterium tuberculosis represents a challenge to antituberculosis drug discovery programs. We previously reported and validated the use of the streptomycin (STR)-dependent M. tuberculosis 18b strain as a tool for assessing drug potency a... |
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Rifamycin Derivatives Are Effective Against Staphylococcal Biofilms In Vitro and Elutable From PMMA.
Clin. Orthop. Relat. Res. 473 , 2874-84, (2015) Local antimicrobial delivery through polymethylmethacrylate beads (PMMA), commonly vancomycin, is used for the treatment of contaminated open fractures but has limited activity against Staphylococcus aureus biofilms, which occur commonly in such fractures. Ri... |
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Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB.
Cochrane Database Syst. Rev. 7 , CD007545, (2013) Preventing active tuberculosis (TB) from developing in people with latent tuberculosis infection (LTBI) is important for global TB control. Isoniazid (INH) for six to nine months has 60% to 90% protective efficacy, but the treatment period is long, liver toxi... |
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High-dose rifapentine with moxifloxacin for pulmonary tuberculosis.
N. Engl. J. Med. 371(17) , 1599-608, (2014) Tuberculosis regimens that are shorter and simpler than the current 6-month daily regimen are needed. |
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Update on rifampin, rifabutin, and rifapentine drug interactions.
Curr. Med. Res. Opin. 29(1) , 1-12, (2013) Rifampin is a potent inducer of both cytochrome P-450 oxidative enzymes and the P-glycoprotein transport system. Among numerous well documented, clinically significant interactions, examples include warfarin, oral contraceptives, itraconazole, digoxin, verapa... |
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Shortening treatment for tuberculosis--to basics.
N. Engl. J. Med. 371(17) , 1642-3, (2014)
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