1,2,4-噻唑-3-丙氨酸
1,2,4-噻唑-3-丙氨酸结构式
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常用名 | 1,2,4-噻唑-3-丙氨酸 | 英文名 | 1H-1,2,4-Triazole-5-propanoicacid, a-amino- |
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| CAS号 | 10109-05-4 | 分子量 | 156.14300 | |
| 密度 | 1.527g/cm3 | 沸点 | 454.1ºC at 760mmHg | |
| 分子式 | C5H8N4O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 228.4ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Incorporation of amino acid analogs during the biosynthesis of Escherichia coli aspartate transcarbamylase.
Biochim. Biophys. Acta 615(1) , 59-69, (1980) Amino acid-requiring mutants capable of producing derepressed levels of aspartate transcarbamylase (carbamoylphosphate:L-aspartate carbamoyltransferase, EC 2.1.3.2) were obtained and used for the incorporation in this enzyme of eight different amino acid anal... |
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Synthesis of a novel histidine analogue and its efficient incorporation into a protein in vivo.
Protein Eng. 16 , 699-706, (2003) Proteins containing unnatural amino acids have immense potential in biotechnology and medicine. We prepared several histidine analogues including a novel histidine analogue, beta-(1,2,3-triazol-4-yl)-DL-alanine. These histidine analogues were assayed for tran... |
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Classifying mutagens as to their specificity in causing the six possible transitions and transversions: a simple analysis using the Salmonella mutagenicity assay.
Environ. Mutagen. 8 , 9, (1986) The standard Salmonella tester strains used to detect base substitution mutations carry the hisG428 ochre mutation (TA102 and TA104) and the hisG46 missense mutation (TA100). These mutations can be reverted by base changes at their mutant his loci or at extra... |
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Simple and efficient synthesis of racemic 2-(tert-butoxycarbon-ylamino)-2-methyl-3-(1H-1,2,4-triazol-1-yl)propanoic acid, a new derivative of β-(1,2,4-triazol-1-yl)alanine.
Molecules 16 , 3380-3390, (2011) A simple synthetic approach to racemic N-tert-butyloxycarbonyl-2-methyl-3-(1H-1,2,4-triazol-1-yl)alanine (5) in four steps and 68% overall yield starting from oxazoline derivative 1 is reported. This synthesis involves the alkylation of 1H-1,2,4-triazole with... |
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Incorporation of an unnatural amino acid in the active site of porcine pancreatic phospholipase A2. Substitution of histidine by 1,2,4-triazole-3-alanine yields an enzyme with high activity at acidic pH.
Protein Eng. 9(4) , 345-52, (1996) The effect of the substitution of the active site histidine 48 by the unnatural 1,2,4-triazole-3-alanine (TAA) amino acid analogue in porcine pancreas phospholipase A2 (PLA2) was studied. TAA was introduced biosynthetically using a his-auxotrophic Escherichia... |
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Incorporation of 1,2,4-triazole-3-alanine into a mutant of phage lambda lysozyme containing a single histidine.
Protein Eng. 11(3) , 213-7, (1998) The only histidine residue in the H31N-H137N double mutant of phage lambda lysozyme (lambdaL), at position 48, was biosynthetically replaced by the analogue 1,2,4-triazole-3-alanine (Taz), the basicity of which is 3 pKa units lower. A histidine-auxotrophic st... |
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First characterization of the mutagenic specificity of 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000) in Salmonella typhimurium.
Mutat. Res. 248(1) , 85-92, (1991) In order to investigate the mutational events induced by the very potent genotoxic agent 7-methoxy-2-nitronaphtho[2,1-b]furan (R7000), we evaluated its mutagenic potency in a battery of his- mutants of Salmonella typhimurium designed to study mutagenic specif... |
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Excretion of amino acids by 1,2,4-triazole-3-alanine-resistant mutants of Methanococcus voltae.
Appl. Environ. Microbiol. 55(5) , 1295-7, (1989) In contrast to wild-type cells, it was found that triazole-alanine-resistant mutants of Methanococcus voltae excreted histidine, proline, phenylalanine, and tyrosine in various combinations. These results suggest that a form of general amino acid biosynthetic... |
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Occurrence of 1,2,4-triazole ring in actinomycetes.
J. Antibiot. 38(8) , 1110-1, (1985)
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Strauss, A., et al.
Plant Cell Tissue Organ Cult. 3 , 123, (1984)
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