8-溴-环二磷酸腺苷核糖
8-溴-环二磷酸腺苷核糖结构式
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常用名 | 8-溴-环二磷酸腺苷核糖 | 英文名 | 8-bromo-cadp-ribose |
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| CAS号 | 151898-26-9 | 分子量 | 620.19700 | |
| 密度 | N/A | 沸点 | N/A | |
| 分子式 | C15H20BrN5O13P2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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Calcium signaling by cyclic ADP-ribose and NAADP. A decade of exploration.
Cell Biochem. Biophys. 28 , 1-17, (1998) Ca2+ mobilization as a signaling mechanism has been placed on center stage with the discovery of the first Ca2+ messenger, inositol trisphosphate (IP3). This article focuses on two new Ca2+ release activators, which mobilize internal Ca2+ stores via mechanism... |
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Intracellular Ca2+ stores could participate to abscisic acid-induced depolarization and stomatal closure in Arabidopsis thaliana.
Plant Signal Behav. 4 , 830-835, (2009) In Arabidopsis thaliana cell suspension, abscisic acid (ABA) induces changes in cytosolic calcium concentration ([Ca(2+)](cyt)) which are the trigger for ABA-induced plasma membrane anion current activation, H(+)-ATPase inhibition, and subsequent plasma membr... |
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Synthesis and characterization of antagonists of cyclic-ADP-ribose-induced Ca2+ release.
Biochim. Biophys. Acta 1178 , 235, (1993) Cyclic ADP-ribose (cADPR) is a naturally-occurring metabolite of NAD+ that is as effective as inositol trisphosphate in mobilizing intracellular Ca2+. A series of analogs modified at the 8-position of the adenine group were synthesized for the investigation o... |
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Actions of cADP-ribose and its antagonists on contraction in guinea pig isolated ventricular myocytes. Influence of temperature.
Circ. Res. 81 , 879-884, (1997) Although it is becoming widely accepted that cADP-ribose (cADPR) can regulate calcium release from the endoplasmic reticulum in sea urchin eggs and in a variety of mammalian cell types, it remains controversial whether this substance might influence calcium r... |
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ADP-ribosyl cyclase and CD38. Multi-functional enzymes in Ca+2 signaling.
Adv. Exp. Med. Biol. 419 , 411, (1997) Mobilization of internal Ca+2 is an important signaling mechanism in cells. In addition to the inositol trisphosphate pathway, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide (NAADP) have been shown to mobilize Ca+2 via independent mechanism... |
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Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+ release in T lymphocyte cell lines.
J. Immunol. 155 , 3353, (1995) Ca2+ release from intracellular stores is one of the major events transducing extracellular signals into living cells. Recently, a metabolite of nicotinamide adenine dinucleotide+ (NAD+), termed "cyclic adenosine diphosphate-ribose" (cADPr), has been describe... |
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MCP-1-activated monocytes induce apoptosis in human retinal pigment epithelium.
Invest. Ophthalmol. Vis. Sci. 52 , 6026-6034, (2011) The inflammatory response in age-related macular degeneration (AMD) is characterized by mononuclear leukocyte infiltration of the outer blood-retina barrier formed by the retinal pigment epithelium (RPE). A key mechanistic element in AMD progression is RPE dy... |
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Contribution of P2X7 receptors to adenosine uptake by cultured mouse astrocytes.
Glia 58 , 1757-1765, (2010) Nucleotides and nucleosides play important roles by maintaining brain homeostasis, and their extracellular concentrations are mainly regulated by ectonucleotidases and nucleoside transporters expressed by astrocytes. Extracellularly applied NAD(+) prevents as... |
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The CD38/cyclic ADP-ribose system: a topological paradox.
Int. J. Biochem. Cell Biol. 29 , 1149-1166, (1997) CD38 was first identified as a lymphocyte differentiation antigen that showed typical properties of an orphan receptor involved in many programs of cell proliferation and activation. However, CD38 proved also to be a bifunctional ectoenzyme that catalyzes the... |
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Complex interactions of NO/cGMP/PKG systems on Ca2+ signaling in afferent arteriolar vascular smooth muscle.
Am. J. Physiol. Heart Circ. Physiol. 298 , H144-H151, (2010) Little is known about the effects of nitric oxide (NO) and the cyclic GMP (cGMP)/protein kinase G (PKG) system on Ca(2+) signaling in vascular smooth muscle cells (VSMC) of resistance vessels in general and afferent arterioles in particular. We tested the hyp... |