12S-HHT
12S-HHT结构式
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常用名 | 12S-HHT | 英文名 | 12S-HHTrE |
|---|---|---|---|---|
| CAS号 | 54397-84-1 | 分子量 | 280.402 | |
| 密度 | 1.0±0.1 g/cm3 | 沸点 | 451.8±45.0 °C at 760 mmHg | |
| 分子式 | C17H28O3 | 熔点 | 151.79 (Mean or Weighted MP)ºC | |
| MSDS | 美版 | 闪点 | 241.1±25.2 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Perfluorinated carboxylic acids inhibit cyclooxygenase pathway more potently than 12-lipoxygenase pathway in rat platelets.
Prostaglandins Leukot. Essent. Fatty Acids 83(4-6) , 225-8, (2010) Two perfluorinated carboxylic acids (PFCAs), pentadecafluorooctanoic acid (PDFOA) and heptadecafluorononanoic acid (HDFNA), were investigated for potential modulatory effects on the cyclooxygenase (COX) and 12-lipoxygenase (LOX) metabolisms in rat platelets. ... |
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Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis.
Pharmacol. Rep. 60(3) , 345-52, (2008) We investigated the influence of recurrent epileptic seizures on the arachidonic acid (AA) cascade in platelets and brain microvessels, using [(14)C]AA as a tracer substrate and chromatographic determination. The recurrent epileptic seizures of male Wistar ra... |
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The anti-inflammatory activities of an extract and compounds isolated fromPlatycladus orientalis(Linnaeus) Francoin vitroandex vivo
J. Ethnopharmacol. 141(2) , 647-52, (2012) As a Chinese traditional herbal medicine, leaves of Platycladus orientalis (Linnaeus) Franco (LPO) are used to treat coughs, excessive mucus secretion, chronic bronchitis, bronchiectasis, and asthma, etc. The experiments were carried out to investigate their ... |
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12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity.
Exp. Mol. Med. 44(6) , 378-86, (2012) 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid (12- HHT) is an enzymatic product of prostaglandin H(2) (PGH(2)) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. Despite the high level of 12-HHT present in tissues and bodily fluids, its ... |
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Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2.
Prostaglandins Other Lipid Mediat. 71(3-4) , 217-34, (2003) Recent studies have shown that long-term in vivo exposure of dogs to neutral sulfur(IV)/sulfite aerosols induces mild inflammatory reactions, whereas the combination of neutral sulfite with acidic sulfur(VI)/sulfate aerosols evokes less pronounced effects. To... |
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Phospholipase A2 activity in platelets of patients with uremia.
Platelets 13(7) , 415-8, (2002) Platelets of patients with uremia develop a defective platelet function and have a decreased production of thromboxane B2 (TxB2). Activated platelets generate thromboxane from free arachidonate that is previously released from the membrane phospholipids (PLs)... |
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Effect of Chia oil (Salvia Hispanica) rich in omega-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma.
Prostaglandins Leukot. Essent. Fatty Acids 77(1) , 21-8, (2007) We investigated the effects of certain dietary polyunsaturated fatty acids (PUFAs) and related eicosanoids on the growth and metastasis formation of a murine mammary gland adenocarcinoma. Salvia hispanica (ChO) and Carthamus tinctorius (SaO) vegetable oil sou... |
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Tetrahydrobiopterin attenuates modulation of platelet 12-lipoxygenase and cyclooxygenase activities by nitric oxide.
Nitric Oxide 5(1) , 77-81, (2001) Endothelial cells secrete large amounts of 5,6,7,8-tetrahydrobiopterin (BH(4)) in septic conditions. BH(4) is a cofactor for nitric oxide (NO) synthase and an essential regulator of its activity. We recently showed that NO can be a modulator of both platelet ... |
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In vivo effects of isatin on rat platelet eicosanoids.
Platelets 16(1) , 39-43, (2005) To establish the possible influence of isatin (2,3-dioxo-indole) on the activity of platelets, the effects of isatin on platelet eicosanoid synthesis were studied in rats. Different doses (12.5-50 mg/kg) of isatin were injected intraperitoneally (i.p.) and th... |
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Determination of the pK(a) of 12-S-hydroxyheptadecatrienoic acid by studies of its vial surface adsorption using high-performance liquid chromatography and liquid scintillation technique.
Chem. Phys. Lipids 99(1) , 95-101, (1999) When dissolving 12-S-hydroxyheptadecatrienoic acid (HHT) in aqueous buffer systems, a partition equilibrium is achieved between the liquid buffer phase and the solid vial phase. This adsorption equilibrium is dependent on the vial material, the ratio of solve... |