羟基积雪草苷
羟基积雪草苷结构式
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常用名 | 羟基积雪草苷 | 英文名 | Madecassoside |
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| CAS号 | 34540-22-2 | 分子量 | 975.121 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 1043.6±65.0 °C at 760 mmHg | |
| 分子式 | C48H78O20 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 295.8±27.8 °C |
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Contact dermatitis due to Centella asiatica.
Contact Dermatitis 62(1) , 54-5, (2010)
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Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials.
Pharm. Biol. 50(12) , 1508-12, (2012) Pentacyclic triterpenes, mainly, asiatic acid, madecassic acid, asiaticoside, and madecassoside are the active constituents of Centella asitica (L.) Urban. (Apiaceae). These compounds possess various pharmacological activities that have been shown to assist w... |
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In vitroinhibitory effects of asiaticoside and madecassoside on human cytochrome P450
Toxicol. In Vitro 25(4) , 890-6, (2011) The inhibitory effects and types of inhibition of asiaticoside and madecassoside on human CYPs were studied in vitro using recombinant human CYPs. The median inhibitory concentrations (IC 50) of asiaticoside and madecassoside were determined for CYP1A2, CYP2C... |
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Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase.
Plant Cell Rep. 29(4) , 403-11, (2010) Farnesyl diphosphate synthase (FPS) plays an essential role in organ development in plants. However, FPS has not previously been identified as a key regulatory enzyme in triterpene biosynthesis. To elucidate the functions of FPS in triterpene biosynthesis, C.... |
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Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress.
J. Biochem. Mol. Toxicol. 26(10) , 399-406, (2012) This study aimed to investigate the effect of madecassoside against oxidative stress-induced injury of endothelial cells. Hydrogen peroxide (H(2)O(2), 500 µmol/L) was employed as an inducer of oxidative stress in human umbilical vein endothelial cells (HUVECs... |
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Simultaneous quantitation of three major triterpenoid glycosides in Centella asiatica extracts by high performance liquid chromatography with evaporative light scattering detection.
Biomed. Chromatogr. 22(2) , 119-24, (2008) A high-performance liquid chromatography method with evaporative light scattering detection was established for simultaneous determination of three major triterpenoid glycosides, i.e. asiaticoside, madecassoside and asiaticoside-B, in Centella asiatica extrac... |
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[Comparative activity of asiaticoside and madecassoside on type I and III collagen synthesis by cultured human fibroblasts].
Ann. Pharm. Fr. 53(1) , 38-42, (1995) Type I and III collagens are the major components of skin dermis. Skin aging is related mainly to a decrease in type I collagen levels. Collagen I also plays an important role in wound healing. An enzyme-linked immunosorbent assay (ELISA) was used to determin... |
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[Preparation of asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb using preparative high performance liquid chromatography].
Se Pu 26(3) , 362-5, (2008) A high performance liquid chromatographic (HPLC) method was successfully used to separate asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb. The raw material containing 20% asiaticoside and 45% madecassoside was dissolved in methan... |
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[Protective effect of madecassoside against reperfusion injury after regional ischemia in rabbit heart in vivo].
Yao Xue Xue Bao 42(5) , 475-80, (2007) This study is to investigate if madecassoside can protect against myocardial reperfusion injury in rabbit heart in vivo. The ischemia reperfusion model was established. Left ventricular function and ECG were monitored at the ischemia and reperfusion period. T... |
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[Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats].
Zhong Xi Yi Jie He Xue Bao 2(6) , 440-4, (2004) To evaluate the effects of madecassoside (MC) on the depression behavior of mice and the activities of monoamine oxidase (MAO) in different rat brain regions.Imipramine as the positive contrast medicine, effects of MC on the depression behavior of mice were o... |