羟基积雪草苷

更新时间：2025-08-20 20:10:00

羟基积雪草苷结构式	常用名	羟基积雪草苷	英文名	Madecassoside
	CAS号	34540-22-2	分子量	975.121
	密度	1.5±0.1 g/cm3	沸点	1043.6±65.0 °C at 760 mmHg
	分子式	C₄₈H₇₈O₂₀	熔点	N/A
	MSDS	美版	闪点	295.8±27.8 °C

羟基积雪草苷用途

Madecassoside是一个从崩大碗中分离出来的五环三萜,有抗炎症。抗氧化和抗衰老的作用。

中文名	羟基积雪草苷
英文名	madecassoside
中文别名	羟基积雪草甙
英文别名	更多

描述	Madecassoside是一个从崩大碗中分离出来的五环三萜,有抗炎症。抗氧化和抗衰老的作用。
相关类别	信号通路 >> 其他 >> 其他天然产物 >> 萜类化合物和糖苷研究领域 >> 其他
参考文献	[1]. Zexin Li et al. Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE2 pathway. Int Immunopharmacol. 2016 Apr;33:24-32. [2]. Xia Y et al. Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-γ in colon. Br J Pharmacol. 2016 Apr;173(7):1219-35 [3]. Su Z et al. Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro. Sci Rep. 2015 Dec 14

描述

Madecassoside是一个从崩大碗中分离出来的五环三萜,有抗炎症。抗氧化和抗衰老的作用。

相关类别

信号通路 >> 其他 >> 其他

天然产物 >> 萜类化合物和糖苷

研究领域 >> 其他

参考文献

[1]. Zexin Li et al. Madecassoside suppresses proliferation and invasiveness of HGF-induced human hepatocellular carcinoma cells via PKC-cMET-ERK1/2-COX-2-PGE2 pathway. Int Immunopharmacol. 2016 Apr;33:24-32.

[2]. Xia Y et al. Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR-γ in colon. Br J Pharmacol. 2016 Apr;173(7):1219-35

[3]. Su Z et al. Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro. Sci Rep. 2015 Dec 14

密度	1.5±0.1 g/cm3
沸点	1043.6±65.0 °C at 760 mmHg
分子式	C₄₈H₇₈O₂₀
分子量	975.121
闪点	295.8±27.8 °C
精确质量	974.508667
PSA	335.44000
LogP	1.88
InChIKey	BNMGUJRJUUDLHW-UGVQVZHUSA-N
SMILES	CC1CCC2(C(=O)OC3OC(COC4OC(CO)C(OC5OC(C)C(O)C(O)C5O)C(O)C4O)C(O)C(O)C3O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC43C)C2C1C
外观性状	白色粉末
蒸汽压	0.0±0.6 mmHg at 25°C
折射率	1.637
储存条件	2-8°C
水溶解性	H2O: soluble1mg/mL, clear, colorless

危害码 (欧洲)	Xn
安全声明 (欧洲)	24/25
危险品运输编码	NONH for all modes of transport
WGK德国	3
RTECS号	YU9625000

Contact dermatitis due to Centella asiatica.

Contact Dermatitis 62(1) , 54-5, (2010)

Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials.

Pharm. Biol. 50(12) , 1508-12, (2012)

Pentacyclic triterpenes, mainly, asiatic acid, madecassic acid, asiaticoside, and madecassoside are the active constituents of Centella asitica (L.) Urban. (Apiaceae). These compounds possess various ...

In vitroinhibitory effects of asiaticoside and madecassoside on human cytochrome P450

Toxicol. In Vitro 25(4) , 890-6, (2011)

The inhibitory effects and types of inhibition of asiaticoside and madecassoside on human CYPs were studied in vitro using recombinant human CYPs. The median inhibitory concentrations (IC 50) of asiat...

Asiaticoside A

MADESOIDE

RederMic

6-Deoxy-α-L-mannopyranosyl-(1->4)-β-D-glucopyranosyl-(1->6)-1-O-[(2α,3β,6β,14β)-2,3,6,23-tetrahydroxy-28-oxours-12-en-28-yl]-β-D-glucopyranose

β-D-Glucopyranose, O-6-deoxy-α-L-mannopyranosyl-(1->4)-O-β-D-glucopyranosyl-(1->6)-1-O-[(2α,3β,6β,14β)-2,3,6,23-tetrahydroxy-28-oxours-12-en-28-yl]-

MADESOSIDE

Madecassoside