微囊藻毒素RR
微囊藻毒素RR结构式
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常用名 | 微囊藻毒素RR | 英文名 | Microcystin RR |
|---|---|---|---|---|
| CAS号 | 111755-37-4 | 分子量 | 1038.200 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | N/A | |
| 分子式 | C49H75N13O12 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 11 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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The conjugation of microcystin-RR by human recombinant GSTs and hepatic cytosol.
Toxicol. Lett. 219(3) , 231-8, (2013) Many cyanobacterial species can produce cyanotoxins, among which mycrocistins (MC) are a group of ≈100 congeners of hepatotoxic cyclic heptapeptides. MC-RR differs from MC-LR, the most studied congener only for one residue (arginine vs leucine), resulting in ... |
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Similar uptake profiles of microcystin-LR and -RR in an in vitro human intestinal model.
Toxicology 290(1) , 7-13, (2011) Microcystins (MCs) are cyclic hepatotoxins produced by various species of cyanobacteria. Their structure includes two variable amino acids (AA) leading to more than 80 MC variants. In this study, we focused on the most common variant, microcystin-LR (MC-LR), ... |
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In vitro and in vivo safety assessment of edible blue-green algae, Nostoc commune var. sphaeroides Kützing and Spirulina plantensis.
Food Chem. Toxicol. 49(7) , 1560-4, (2011) Blue-green algae (BGA) have been consumed as food and herbal medicine for centuries. However, safety for their consumption has not been well investigated. This study was undertaken to evaluate in vitro and in vivo toxicity of cultivated Nostoc commune var. sp... |
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Antioxidant response in liver of the phytoplanktivorous bighead carp (Aristichthys nobilis) intraperitoneally-injected with extracted microcystins.
Fish Physiol. Biochem. 36(2) , 165-72, (2010) The worldwide occurrence of cyanobacterial blooms makes it necessary to perform environmental risk assessment procedures to monitor the effects of microcystins (MCs) on fish. Oxidative stress biomarkers are valuable tools in this regard. In the present study,... |
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Removal of a potent cyanobacterial hepatotoxin by peat.
J. Environ. Sci. Health. A. Tox. Hazard. Subst. Environ. Eng. 45(14) , 1877-84, (2010) Microcystins (cyclic heptapeptides), produced by a number of freshwater cyanobacteria, are of health concern in potable water supplies. In this article, the adsorptive removal of microcystin-RR (MCRR) from the aqueous solution by a low-cost adsorbent, peat, w... |
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The apoptotic effect of oral administration of microcystin-RR on mice liver.
Environ. Toxicol. 26(5) , 443-52, (2011) Microcystin produced by cyanobacteria in diverse water systems is a potent hepatotoxin that has been documented to induce hepatocyte apoptosis and liver injury. There are more than eighty reported microcystins. The present work aimed at investigating the apop... |
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Morphological and ultrastructural changes in tobacco BY-2 cells exposed to microcystin-RR.
Chemosphere 76(7) , 1006-12, (2009) Tobacco BY-2 cells were exposed to microcystin-RR (MC-RR) at two concentrations, 60 microg mL(-1) and 120 microg mL(-1), to study the changes in morphology and ultrastructure of cells as a result of the exposure. Exposure to the lower concentration for 5 d le... |
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Transcriptomic comparison of cyanotoxin variants in a human intestinal model revealed major differences in oxidative stress response: Effects of MC-RR and MC-LR on Caco-2 cells
Ecotoxicol. Environ. Saf. 82 , 13-21, (2012) Microcystins (MCs) are cyclic hepatotoxins produced by various species of cyanobacteria. Their structure includes two variable amino acids (AA) giving rise to more than 90 MC variants, however most of the studies to date have focused on the most toxic variant... |
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Microbial biodegradation of microcystin-RR by bacterium Sphingopyxis sp. USTB-05.
J. Environ. Sci. (China) 22(2) , 168-75, (2010) A strain, USTB-05, isolated from Lake Dianchi, China, degraded the cyanobacterial toxin microcystin-RR (MC-RR) at the rate of 16.7 mg/L per day. Analysis of 16S rDNA sequence showed that the strain was Sphingopyxis sp. Enzymatic degradation pathways for MC-RR... |
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Highly sensitive detection and discrimination of LR and YR microcystins based on protein phosphatases and an artificial neural network.
Anal. Bioanal. Chem 404(3) , 711-20, (2012) The inhibition characteristics of three different protein phosphatases by three microcystin (MC) variants--LR, YR, and RR--were studied. The corresponding K (I) for each enzyme-MC couple was calculated. The toxicity of MC varies in the following order: MC-LR ... |