土大黄甙
土大黄甙结构式
|
常用名 | 土大黄甙 | 英文名 | GSK690693 |
|---|---|---|---|---|
| CAS号 | 937174-76-0 | 分子量 | 425.484 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 683.8±65.0 °C at 760 mmHg | |
| 分子式 | C21H27N7O3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 367.3±34.3 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
|
Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway.
J. Pathol. 234(2) , 152-63, (2014) Morgana/CHP-1 is a ubiquitously expressed protein able to inhibit ROCK II kinase activity. We have previously demonstrated that morgana haploinsufficiency leads to multiple centrosomes, genomic instability, and higher susceptibility to tumour development. Whi... |
|
|
Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC Cells.
Mol. Cancer Ther. 14 , 1805-15, (2015) mTOR is aberrantly activated in hepatocellular carcinoma (HCC) and plays pivotal roles in tumorigenesis and chemoresistance. Rapamycin has been reported to exert antitumor activity in HCC and sensitizes HCC cells to cytotoxic agents. However, due to feedback ... |
|
|
Synergistic Effects between mTOR Complex 1/2 and Glycolysis Inhibitors in Non-Small-Cell Lung Carcinoma Cells.
PLoS ONE 10 , e0132880, (2015) Cancer metabolism has greatly interested researchers. Mammalian target of rapamycin (mTOR) is dysregulated in a variety of cancers and considered to be an appealing therapeutic target. It has been proven that growth factor signal, mediated by mTOR complex 1 (... |
|
|
MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells.
Oncotarget 5(19) , 8893-905, (2014) Non-small cell lung cancers (NSCLCs) that harbor an oncogenic KRAS mutation are often associated with resistance to targeted therapies. The MUC1-C transmembrane protein is aberrantly overexpressed in NSCLCs and confers a poor outcome; however, the functional ... |
|
|
The PTEN-AKT-mTOR/RICTOR Pathway in Nasal Natural Killer Cell Lymphoma Is Activated by miR-494-3p via PTEN But Inhibited by miR-142-3p via RICTOR.
Am. J. Pathol. 185 , 1487-99, (2015) Nasal natural killer (NK) cell lymphoma (NNL) is an Epstein-Barr virus-associated lymphoma of cytotoxic NK cell origin. The Epstein-Barr virus-encoded miR-BART20-5p inhibits T-bet (TBX21), the master transcription factor of cytotoxic NK cells. To further expl... |
|
|
Synergistic apoptosis in head and neck squamous cell carcinoma cells by co-inhibition of insulin-like growth factor-1 receptor signaling and compensatory signaling pathways.
Head Neck 37 , 1722-32, (2016) In head and neck squamous cell carcinoma (HNSCC), resistance to single-agent targeted therapy may be overcome by co-targeting of compensatory signaling pathways.A targeted drug screen with 120 combinations was used on 9 HNSCC cell lines.Multiple novel drug co... |
|
|
Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552.
Am. J. Physiol. Cell Physiol. 310 , C542-57, (2016) Given the fundamental role of β-catenin signaling in intestinal epithelial cell proliferation and the growth-promoting function of protein kinase D1 (PKD1) in these cells, we hypothesized that PKDs mediate cross talk with β-catenin signaling. The results pres... |
|
|
Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis.
Oncotarget 6 , 43342-62, (2016) Activated in response to chemotherapy, senescence is a tumor suppressive mechanism that induces a permanent loss of proliferation. However, in response to treatment, it is not really known how cells can escape senescence and how irreversible or incomplete thi... |
|
|
Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads.
Hum. Mol. Genet. 24 , 6687-98, (2015) Juvenile granulosa cell tumors (JGCTs) of the ovary are pediatric neoplasms representing 5% of all granulosa cell tumors (GCTs). Most GCTs are of adult type (AGCTs) and bear a mutation in the FOXL2 gene. The molecular basis of JGCTs is poorly understood, alth... |
|
|
Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer.
Oncogene 33(22) , 2846-56, (2014) The Y-box binding protein-1 (YB-1) transcription factor is associated with unfavorable clinical outcomes. However, the mechanisms underlying this association remain to be fully elucidated. We demonstrate that YB-1 phosphorylation, indicative of YB-1 activatio... |