![]() 5,6-双(苯基氨基)异吲哚啉-1,3-二酮结构式
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常用名 | 5,6-双(苯基氨基)异吲哚啉-1,3-二酮 | 英文名 | CGP 52411 |
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CAS号 | 145915-58-8 | 分子量 | 329.35200 | |
密度 | 1.374 g/cm3 | 沸点 | N/A | |
分子式 | C20H15N3O2 | 熔点 | 199-202℃ | |
MSDS | 美版 | 闪点 | N/A |
A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells.
Mol. Syst. Biol. 11 , 846, (2015) Small molecules often affect multiple targets, elicit off-target effects, and induce genotype-specific responses. Chemical genetics, the mapping of the genotype dependence of a small molecule's effects across a broad spectrum of phenotypes can identify novel ... |
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Umbelliferone and daphnetin ameliorate carbon tetrachloride-induced hepatotoxicity in rats via nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1 expression
Environ. Toxicol. Pharmacol. 38(2) , 531-41, (2014) • This study demonstrates the hepatoprotective effect of umbelliferone and daphnetin. • Both coumarins ameliorate CCl4-induced oxidative stress and hepatotoxicity. • This effect is mediated via the nuclear translocation and accumulation of Nrf2. • Nrf2 up-reg... |
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Gene activation and protein expression following ischaemic stroke: strategies towards neuroprotection.
J. Cell. Mol. Med. 9 , 85-102, (2005) Current understanding of the patho-physiological events that follow acute ischaemic stroke suggests that treatment regimens could be improved by manipulation of gene transcription and protein activation, especially in the penumbra region adjacent to the infar... |
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Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule.
Proc. Natl. Acad. Sci. U. S. A. 101 , 14326-14332, (2004) The Abeta1-42 peptide that is overproduced in Alzheimer's disease (AD) from a large precursor protein has a normal amino acid sequence but, when liberated, misfolds at neutral pH to form "protofibrils" and fibrils that are rich in beta-sheets. We find that th... |
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