5-甲氧基-2-甲基-3-吲哚乙酸
5-甲氧基-2-甲基-3-吲哚乙酸结构式
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常用名 | 5-甲氧基-2-甲基-3-吲哚乙酸 | 英文名 | 5-methoxy-2-methyl-3-indoleacetic acid |
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| CAS号 | 2882-15-7 | 分子量 | 219.23700 | |
| 密度 | 1.292g/cm3 | 沸点 | 450.2ºC at 760mmHg | |
| 分子式 | C12H13NO3 | 熔点 | 161-163 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 226.1ºC |
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HPLC analysis of indomethacin and its impurities in capsule and suppository formulations.
J. Pharm. Sci. 71(7) , 828-30, (1982) Indomethacin and its impurities in suppository and capsule formulations were quantitatively determined by HPLC using a reversed-phase, octadecyl column and a mobile phase of methanol-water-acetonitrile-acetic acid (55:35:10:1). Analysis of the suppository for... |
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Accurate assignment of ethanol origin in postmortem urine: liquid chromatographic-mass spectrometric determination of serotonin metabolites.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 805(2) , 223-34, (2004) Toxicological examination of fatal aviation accident victims routinely includes analysis of ethanol levels. However, distinguishing between antemortem ingestion and postmortem microbial formation complicates all positive ethanol results. Development of a sing... |
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Simultaneous densitometric determination of indomethacin and its degradation products, 4-chlorobenzoic acid and 5-methoxy-2-methyl-3-indoleacetic acid, in pharmaceutical preparations.
J. AOAC Int. 84(6) , 1703-7, (2001) A densitometric method was developed for the identification and determination of indomethacin and its degradation products, 4-chlorobenzoic acid and 5-methoxy-2-methyl-3-indoleacetic acid, in pharmaceuticals. To separate these compounds, silica gel-coated thi... |
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Axonal injury-dependent induction of the peripheral benzodiazepine receptor in small-diameter adult rat primary sensory neurons.
Eur. J. Neurosci. 20(3) , 671-83, (2004) The peripheral benzodiazepine receptor (PBR), a benzodiazepine but not gamma-aminobutyric acid-binding mitochondrial membrane protein, has roles in steroid production, energy metabolism, cell survival and growth. PBR expression in the nervous system has been ... |
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Expression of mitochondrial benzodiazepine receptor and its putative endogenous ligand diazepam binding inhibitor in cultured primary astrocytes and C-6 cells: relation to cell growth.
Cell Growth Differ. 5(9) , 1005-14, (1994) A recognition site for benzodiazepines structurally different from that linked to the gamma-aminobutyric acid receptor subtype A or the "central type" benzodiazepine receptor has been located mainly in the outer membranes of mitochondria and designated mitoch... |
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High-performance liquid chromatographic method for the determination of indomethacin and its two primary metabolites in urine.
J. Chromatogr. A. 306 , 315-21, (1984) Quantitation of total amounts (i.e., free compound plus glucuronide conjugate) of indomethacin (INDO) and its deschlorobenzoyl (DBI) and desmethyl (DMI) metabolites in human urine is described. An aliquot (0.4 ml) of urine is incubated with glucuronidase (100... |
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Cytostatic activity of pharmacological concentrations of indomethacin in cell cultures and inactivity of closely related compounds.
Biochem. Pharmacol. 30(7) , 807-9, (1981)
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5-methoxy-2-methyl-3-indole acetic acid, a metabolite and alkali hydrolysis product of indomethacin, inhibits platelet aggregation, in vivo.
Prostaglandins 21(4) , 667-73, (1981) Previous studies suggested that one of the hydrolysis products of indomethacin, either 4-chlorobenzoic acid or 5-methoxy-2-methyl-3-indole acetic acid, can inhibit platelet aggregation in vivo. If correct, this hypothesis explains the apparent action of indom... |
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In vitro effect of endozepines on frog adrenocortical cells.
Ann. N. Y. Acad. Sci. 839 , 596-7, (1998)
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Five methoxy-2-methyl-3-indole acetic acid. A metabolite and alkali hydrolysis product of indomethacin, markedly inhibits platelet aggregation only in the presence of aorta or a product released by aorta.
Prostaglandins. Leukot. Med. 8(2) , 125-32, (1982) 5-methoxy-2-methyl-3-indole acetic acid (5MIAA) is a metabolite and alkali hydrolysis product of indomethacin. This indole derivative was previously found to be an effective in vivo inhibitor of platelet aggregation in an experimental model of microvascular i... |