2-甲基-1,3-二氧戊环
2-甲基-1,3-二氧戊环结构式
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常用名 | 2-甲基-1,3-二氧戊环 | 英文名 | 1,3-Dioxolane,2-methyl- |
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| CAS号 | 497-26-7 | 分子量 | 88.10510 | |
| 密度 | 0.99 | 沸点 | 82-83 °C(lit.) | |
| 分子式 | C4H8O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 28 °F | |
| 符号 |
GHS02, GHS07 |
信号词 | Danger |
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Muscarinic cholinergic receptors in the embryonic chick heart: interaction of agonist, receptor, and guanine nucleotides studied by an improved assay for direct binding of the muscarinic agonist [3H]cismethyldioxolane.
Mol. Pharmacol. 32(1) , 230-40, (1987) Muscarinic agonist binding has been studied by the indirect method of competition between binding of agonist and 3H-antagonist. Studies of 3H-agonist binding have either been complicated by high levels of nonspecific binding or have been carried out at low co... |
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Potency ratio for the inhibition of 3H-QNB and 3H-cis-methyldioxolane binding predicts agonist or antagonist activity on muscarinic receptors.
Methods Find. Exp. Clin. Pharmacol. 10(10) , 619-21, (1988) 3H-Quinuclidinyl benzylate (3H-QNB) and 3H-cis-methyldioxolane (3H-CD) binding to cholinergic muscarinic receptors have been carried out on the same membrane preparation from the rat brain cortex. Inhibition of 3H-QNB and 3H-CD binding by cholinergic muscarin... |
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Binding studies with [3H]cis-methyldioxolane in different tissues. Under certain conditions [3H]cis-methyldioxolane labels preferentially but not exclusively agonist high affinity states of muscarinic M2 receptors.
Naunyn Schmiedebergs Arch. Pharmacol. 335(4) , 372-7, (1987) Special conditions--tricine buffer containing Ca2+ and Mg2+, 22 degrees C (TCM)--allow to label a much higher proportion of muscarinic receptors by [3H]cis-methyldioxolane (CD) than hitherto described (Vickroy et al. 1984a). Taking the maximum number of bindi... |
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Muscarinic M3 receptors mediate contractions in rabbit, endothelium-denuded aorta in vitro.
J. Auton. Pharmacol. 14(4) , 283-93, (1994) 1. Muscarinic receptors mediating contraction of rabbit endothelium-denuded aorta have been characterized functionally, in vitro, using a range of antagonists (atropine, pirenzepine, methoctramine, himbacine, 4-diphenyl-acetoxy-N-methyl piperidine methiodide ... |
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cis-Methyldioxolane specifically recognizes the m2 muscarinic receptor.
J. Neurochem. 62(1) , 388-91, (1994) cis-Methyldioxolane (CD) is a muscarinic receptor agonist. [3H]CD has been used to label a subpopulation of muscarinic receptors described as exhibiting high agonist affinity. Pharmacological evidence suggests that the population of receptors labeled by [3H]C... |
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Cholinergic antagonists and REM sleep generation.
Brain Res. 543(1) , 175-9, (1991) In this study we extended our observations on the role of M1 and M2 muscarinic receptors in mediating the cholinergic induction of REM sleep. Cats were chronically implanted with sleep recording electrodes and microinjections of Ringer's or muscarinic antagon... |
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M2 muscarinic receptors mediate pressor responses to cholinergic agonists in the ventrolateral medullary pressor area.
Brain Res. 449(1-2) , 141-9, (1988) Microinjections of cholinergic agonists into the ventrolateral medullary pressor area (VLPA) evoke increase in blood pressure (BP) and heart rate (HR). Recently two major subtypes of muscarinic receptors (M1 and M2) have been identified. This investigation wa... |
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Synthesis and SAR of bulky 1-azabicyclo[2.2.1]-3-one oximes as muscarinic receptor subtype selective agonists.
Life Sci. 52(5-6) , 505-11, (1993) The synthesis of a series of potent and efficacious 1-azabicyclo[2.2.1]heptan-3-one oxime muscarinic agonists is described. The oximes have extended appendages designed to span the cavity defined by the seven transmembrane helices of the muscarinic receptor. ... |
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Cholinergic agents: effect of methyl substitution in a series of arecoline derivatives on binding to muscarinic acetylcholine receptors.
J. Pharm. Sci. 81 , 1015-1019, (1992) Arecoline, arecaidine, and a series of derivatives, differing by the presence or absence of methyl groups at positions on the periphery of the molecule, were prepared, and their binding to muscarinic acetylcholine receptors was tested. On the basis of this st... |
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[Determination of acetylcholine by inhibition of the specific binding of tritiated cis-methyldioxolane: application to the study of the effects of acetylcholine accumulation in a murine neuroblastoma culture].
C. R. Seances. Soc. Biol. Fil. 178(5) , 526-34, (1984) The radioreceptor assay for acetylcholine (ACh) is based on the ability of the ACh to compete with the specific binding of [3H] cis-methyldioxolane to muscarinic receptors of rat cerebral cortex membranes. The technique described was used to measure ACh level... |