试卤灵
试卤灵结构式
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常用名 | 试卤灵 | 英文名 | Resorufin |
|---|---|---|---|---|
| CAS号 | 635-78-9 | 分子量 | 213.18900 | |
| 密度 | 1.46 g/cm3 | 沸点 | 413ºC at 760 mmHg | |
| 分子式 | C12H7NO3 | 熔点 | >300 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 203.6ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Membrane anchor of cytochrome P450 reductase suppresses the uncoupling of cytochrome P450.
Chem. Pharm. Bull. 63(4) , 286-94, (2015) Cytochrome P450 reductase (CPR) is an important redox partner of microsomal CYPs. CPR is composed of a membrane anchor and a catalytic domain that contains FAD and flavin mononucleotide (FMN) as redox centers and mediates electron transfer to CYP. Although th... |
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Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.
ChemMedChem 10(2) , 253-65, (2015) At present, inhibitors of α/β-hydrolase domain 6 (ABHD6) are viewed as a promising approach to treat inflammation and metabolic disorders. This article describes the development of 1,2,5-thiadiazole carbamates as ABHD6 inhibitors. Altogether, 34 compounds wer... |
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Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblasts.
Biochim. Biophys. Acta 1842(12 Pt A) , 2468-78, (2014) The cardiotoxicity induced by the anti-cancer doxorubicin involves increased oxidative stress, disruption of calcium homeostasis and activation of cardiomyocyte death. Nevertheless, antioxidants and caspase inhibitors often show little efficacy in preventing ... |
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Effects of carcinogenic versus non-carcinogenic AHR-active PAHs and their mixtures: lessons from ecological relevance.
Environ. Res. 138 , 101-11, (2015) Polycyclic aromatic hydrocarbons (PAHs) are priority environmental mutagens and carcinogens that occur in the aquatic environment as mixtures rather than the individual compounds for which guidelines are issued. The present work aimed at understanding the int... |
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Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2).
Arch. Toxicol. 89 , 1329-36, (2015) Small molecular weight protein kinase inhibitors are frequently used tools to unravel the complex network of cellular signal transduction under certain physiological and pathophysiological conditions. 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d... |
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Analysis of the AHR gene proximal promoter GGGGC-repeat polymorphism in lung, breast, and colon cancer.
Toxicol. Appl. Pharmacol. 282(1) , 30-41, (2014) The aryl hydrocarbon receptor (AhR) regulates expression of numerous genes, including those of the CYP1 gene family. With the goal of determining factors that control AHR gene expression, our studies are focused on the role of the short tandem repeat polymorp... |
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Expression of aryl hydrocarbon receptor 1 (AHR1), AHR1 nuclear translocator 1 (ARNT1) and CYP1 family monooxygenase mRNAs and their activity in chicken ovarian follicles following in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Toxicol. Lett. 237 , 100-11, (2015) The aim of this in vitro study was to determine the effect of TCDD and luteinizing hormone (LH) on mRNA expression of aryl hydrocarbon receptor 1 (AHR1), AHR1 nuclear translocator 1 (ARNT1), and the CYP1 family monooxygenases (CYP1A4, CYP1A5, CYP1B1), and to ... |
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Potentiating effect of graphene nanomaterials on aromatic environmental pollutant-induced cytochrome P450 1A expression in the topminnow fish hepatoma cell line PLHC-1.
Environ. Toxicol. 30 , 1192-204, (2015) Graphene and its derivatives are an emerging class of carbon nanomaterial with great potential for a broad range of industrial and consumer applications. However, their increasing production and use is expected to result in release of nano-sized graphene plat... |
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Novel Marmoset Cytochrome P450 2C19 in Livers Efficiently Metabolizes Human P450 2C9 and 2C19 Substrates, S-Warfarin, Tolbutamide, Flurbiprofen, and Omeprazole.
Drug Metab. Dispos. 43 , 1408-16, (2015) The common marmoset (Callithrix jacchus), a small New World monkey, has the potential for use in human drug development due to its evolutionary closeness to humans. Four novel cDNAs, encoding cytochrome P450 (P450) 2C18, 2C19, 2C58, and 2C76, were cloned from... |
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Effects of BDE-209 and its mixtures with BDE-47 and BDE-99 on multiple biomarkers in Carassius auratus
Environ. Toxicol. Pharmacol. 38(2) , 554-61, (2014) • Biomarkers including AChE, EROD, GST, SOD and CAT were used. • The toxicity order of PBDEs was proposed via the integrated biomarker response. • The mixtures showed more negative biological effects than BDE-209 alone. |