噻唑
噻唑结构式
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常用名 | 噻唑 | 英文名 | Thiazole |
|---|---|---|---|---|
| CAS号 | 288-47-1 | 分子量 | 85.128 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 116.5±9.0 °C at 760 mmHg | |
| 分子式 | C3H3NS | 熔点 | -33°C | |
| MSDS | 中文版 美版 | 闪点 | 22.2±0.0 °C | |
| 符号 |
GHS02, GHS05, GHS07 |
信号词 | Danger |
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CYP3A5 regulates prostate cancer cell growth by facilitating nuclear translocation of AR.
Prostate 75(5) , 527-38, (2015) The central role of androgen receptor (AR) signaling is established in prostate cancer growth and progression. We propose CYP3A5 is part of a feedback loop that modulates the sensitivity of AR to androgen exposure. The purpose of this study is to elucidate th... |
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Cytotoxic and apoptotic effects of synthetic benzochromene derivatives on human cancer cell lines.
Naunyn Schmiedebergs Arch. Pharmacol. 387(12) , 1199-208, (2014) With the aim of discovering potential cytotoxic agents, a series of benzochromene derivatives were screened for their cytotoxic activity against seven human cancer cell lines by standard 3-(4, 5-dimethyl thiazol)-2,5-diphenyl tetrazolium bromide (MTT) assay. ... |
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Bioactive thermoresponsive polyblend nanofiber formulations for wound healing.
Mater. Sci. Eng. C. Mater. Biol. Appl. 48 , 126-37, (2015) The rationale of this work is to develop new bioactive thermoresponsive polyblend nanofiber formulations for wound healing (topical). Various polymer compositions of thermoresponsive, poly(N-isopropylacrylamide), egg albumen and poly(ε-caprolactone) blend sol... |
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Structure-function relationships in histidine-rich antimicrobial peptides from Atlantic cod.
Biochim. Biophys. Acta 1848 , 1451-61, (2015) Gad-1 and Gad-2 are antimicrobial peptide (AMP) sequences encoded by paralogous genes. They are rich in histidine, which suggests that their activity might be pH-dependent. We examined their structure-function relationships with a view to learning how to impr... |
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Acthi, a thiazole biosynthesis enzyme, is essential for thiamine biosynthesis and CPC production in Acremonium chrysogenum.
Microb. Cell Fact. 14 , 50, (2015) The filamentous fungus Acremonium chrysogenum is an important industrial fungus and is used in the production of the β-lactam antibiotic cephalosporin C. Little is known regarding the molecular and biological mechanisms of how this industrial strain was impro... |
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Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil.
Cancer Biol. Ther. 16 , 1259-68, (2015) Schweinfurthins are intriguing natural products with anti-cancer activities and as yet incompletely understood mechanisms of action. We investigated whether inhibitors of P-glycoprotein (Pgp), in a manner analogous to other natural products, might enhance sch... |
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The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2.
Cell Cycle 14 , 2688-700, (2015) E3 ubiquitin ligases have been implicated in the ubiquitination and proteasome-mediated degradation of several key regulators of cell cycle. Owing to their pleotropic behavior, E3 ubiquitin ligases are tightly regulated both at transcriptional and post-transl... |
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Synthesis, antibacterial, antioxidant activity and QSAR studies of novel 2-arylidenehydrazinyl-4-arylthiazole analogues.
Chem. Pharm. Bull. 62(12) , 1259-68, (2014) A novel series of 2-arylidenehydrazinyl-4-arylthiazole analogues (3a-p) was designed and synthesized in excellent yields using a rapid, simple, efficient methodology. Sixteen novel compounds were screened for in vitro antimicrobial activities against eleven b... |
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Role of integrin-linked kinase in drug resistance of lung cancer.
Onco. Targets Ther. 8 , 1561-5, (2015) The objective of the present investigation was to investigate the role of integrin-linked kinase (ILK) in the gemcitabine-resistant lung cancer cell line A549 and explore the underlying mechanism.Gemcitabine-resistant A549 (A549/GemR) cell line was establishe... |
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The Biosynthesis of the Thiazole Moiety of Thiamin in the Archaeon Halobacterium salinarum.
J. Nutr. Sci. Vitaminol. 61 , 270-4, (2015) The biosynthetic pathways of the thiazole moiety of thiamin were studied in the archaeon Halobacterium salinarum. Thiamin is generated by the union of 4-amino-5-hydroxymethyl-2-methylpyrimidine (pyrimidine) and 5-(2-hydroxyethyl)-4-methylthiazole (thiazole). ... |